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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Peptidomimetics and Peptide-Based Blockbuster Drugs

Author(s): Jianlin Han, Hiroyuki Konno, Tatsunori Sato, Kunisuke Izawa* and Vadim A. Soloshonok*

Volume 25, Issue 14, 2021

Published on: 06 July, 2021

Page: [1627 - 1658] Pages: 32

DOI: 10.2174/1385272825666210610155047

Price: $65


Amino acids (AAs) play an important role in the modern health industry. The aim of this article was to assess that AAs’ residues are frequently found in the structures of smallmolecule modern pharmaceuticals, while peptidomimetics and peptide-based drugs are entirely derived from AAs. Currently, AAs serve as key structural features in numerous successful pharmaceuticals, so-called blockbuster drugs. In this work, we provide a detailed profile of 5 peptidomimetics and 4 peptide drugs. For each compound, we describe the spectrum of biological activity, medicinal chemistry discovery, and synthetic preparation.

Keywords: Tailor-made amino acids, blockbuster drugs, peptidomimetic, peptides, modern pharmaceuticals, drug design and development, asymmetric synthesis.

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