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Current Neuropharmacology

Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Systematic Review Article

Cognitive Impairment Following Clinical or Recreational Use of Gammahydroxybutyric Acid (GHB): A Systematic Review

Author(s): Jan Van Amsterdam*, Tibor M. Brunt, Filipa R. Pereira, Cleo L. Crunelle and Wim Van Den Brink

Volume 20, Issue 4, 2022

Published on: 24 February, 2022

Page: [809 - 819] Pages: 11

DOI: 10.2174/1570159X19666210610094352

Price: $65

Abstract

Background: GHB (gamma-hydroxybutyric acid; sodium oxybate) is a general anaesthetic that is clinically used for the treatment of narcolepsy, cataplexy, alcohol withdrawal and alcohol relapse prevention. In addition, GHB is recreationally used. Most clinical and recreational users regard GHB as an innocent drug devoid of adverse effects, despite its high dependence potential and possible neurotoxic effects. At high doses, GHB may lead to a comatose state. This paper systematically reviews possible cognitive impairments due to clinical and recreational GHB use.

Methods: PubMed and PsychINFO were searched for literature data about the acute and residual cognitive deficits following GHB use. This review is conducted using the PRISMA protocol.

Results: A total of 43 reports covering human and animal data on GHB-induced cognitive impairments were eligible and reviewed. This systematic review found no indication for cognitive impairments after clinical GHB use. However, it supports the view that moderate GHB use may result in acute short-term cognitive impairments, whereas regular high-dose GHB use and/or multiple GHB-induced comas are probably neurotoxic resulting in long-term residual cognitive impairments.

Conclusion: These results emphasize the need for awareness among clinicians and recreational users to minimize negative health consequences of recreational GHB use, particularly when high doses are used and GHB-induced comas occur.

Keywords: GHB, Xyrem, illicit drugs, sodium oxybate, anaesthetic, neurotoxicity, cognition, memory.

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[1]
Kam, P.C.; Yoong, F.F. Gamma-hydroxybutyric acid: an emerging recreational drug. Anaesthesia, 1998, 53(12), 1195-1198.
[http://dx.doi.org/10.1046/j.1365-2044.1998.00603.x] [PMID: 10193223]
[2]
Vickers, M.D. Gammahydroxybutyric acid. Int. Anesthesiol. Clin., 1969, 7(1), 75-89.
[http://dx.doi.org/10.1097/00004311-196900710-00007] [PMID: 5392628]
[3]
WHO. World Health Organisation (WHO). WHO Expert Committee on Drug Dependence, 36th Report. Gamma-hydroxybutyric acid (GHB). Critical Review Report. 35th ECDD. WHO Publications; Geneva, Switzwerland. 2012. Available from:. https://www.who.int/medicines/areas/quality_safety/4.1GHBcritical_review.pdf?ua=1 (Accessed 30 August 2020).
[4]
Bogan, R.K.; Roth, T.; Schwartz, J.; Miloslavsky, M. Time to response with sodium oxybate for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy. J. Clin. Sleep Med., 2015, 11(4), 427-432.
[http://dx.doi.org/10.5664/jcsm.4598] [PMID: 25580605]
[5]
Xu, X.M.; Wei, Y.D.; Liu, Y.; Li, Z.X. Gamma-hydroxybutyrate (GHB) for narcolepsy in adults: an updated systematic review and meta-analysis. Sleep Med., 2019, 64, 62-70.
[http://dx.doi.org/10.1016/j.sleep.2019.06.017] [PMID: 31671326]
[6]
Addolorato, G.; Lesch, O.M.; Maremmani, I.; Walter, H.; Nava, F.; Raffaillac, Q.; Caputo, F. Post-marketing and clinical safety experience with sodium oxybate for the treatment of alcohol withdrawal syndrome and maintenance of abstinence in alcohol-dependent subjects. Expert Opin. Drug Saf., 2020, 19(2), 159-166.
[http://dx.doi.org/10.1080/14740338.2020.1709821] [PMID: 31876433]
[7]
Sumnall, H.R.; Woolfall, K.; Edwards, S.; Cole, J.C.; Beynon, C.M. Use, function, and subjective experiences of gamma-hydroxybutyrate (GHB). Drug Alcohol Depend., 2008, 92(1-3), 286-290.
[http://dx.doi.org/10.1016/j.drugalcdep.2007.07.009] [PMID: 17766059]
[8]
van den Brink, W.; Addolorato, G.; Aubin, H.J.; Benyamina, A.; Caputo, F.; Dematteis, M.; Gual, A.; Lesch, O.M.; Mann, K.; Maremmani, I.; Nutt, D.; Paille, F.; Perney, P.; Rehm, J.; Reynaud, M.; Simon, N.; Söderpalm, B.; Sommer, W.H.; Walter, H.; Spanagel, R. Efficacy and safety of sodium oxybate in alcohol-dependent patients with a very high drinking risk level. Addict. Biol., 2018, 23(4), 969-986.
[http://dx.doi.org/10.1111/adb.12645] [PMID: 30043457]
[9]
Amato, L.; Minozzi, S.; Davoli, M. Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome. Cochrane Database Syst. Rev., 2011, 2011(6) ,CD008537.
[http://dx.doi.org/10.1002/14651858.CD008537.pub2] [PMID: 21678378]
[10]
EMA. European Medicines Agency (EMA). Assessment report Alcover (granules in sachet) and associated names; sodium oxybate. Procedure number: EMEA/H/A-29(4)/1451. 2017. Available 816 Current Neuropharmacology, 2022, Vol. 20, No. 4 Amsterdam et al. from: . https://www.ema.europa.eu/en/documents/referral/alcover-article-294-referral-assessment-report_en.pdf
[11]
Beurmanjer, H.; Kamal, R.M.; de Jong, C.A.J.; Dijkstra, B.A.G.; Schellekens, A.F.A. Baclofen to prevent relapse in gamma-hydroxybutyrate (ghb)-dependent patients: a multicentre, open-label, non-randomized, controlled trial. CNS Drugs, 2018, 32(5), 437-442.
[http://dx.doi.org/10.1007/s40263-018-0516-6] [PMID: 29651711]
[12]
Dijkstra, B.A.; Kamal, R.; van Noorden, M.S.; de Haan, H.; Loonen, A.J.; De Jong, C.A. Detoxification with titration and tapering in gamma-hydroxybutyrate (GHB) dependent patients: The Dutch GHB monitor project. Drug Alcohol Depend., 2017, 170, 164-173.
[http://dx.doi.org/10.1016/j.drugalcdep.2016.11.014] [PMID: 27923198]
[13]
de Jong, C.A.; Kamal, R.; Dijkstra, B.A.; de Haan, H.A. Gamma-hydroxybutyrate detoxification by titration and tapering. Eur. Addict. Res., 2012, 18(1), 40-45.
[http://dx.doi.org/10.1159/000333022] [PMID: 22142784]
[14]
Galloway, G.P.; Frederick-Osborne, S.L.; Seymour, R.; Contini, S.E.; Smith, D.E. Abuse and therapeutic potential of gamma-hydroxybutyric acid. Alcohol, 2000, 20(3), 263-269.
[http://dx.doi.org/10.1016/S0741-8329(99)00090-7] [PMID: 10869868]
[15]
SAMHSA. Substance Abuse and Mental Health Services Administration (SAMHSA). Results from the 2018 National Survey on Drug Use and Health: Detailed tables. Rockville, MD: Center for Behavioral Health Statistics and Quality, SAMHSA. 2019. Available from:. https://www.samhsa.gov/data/Accessed 25 August
[16]
ESPAD. European School Survey Project on Alcohol and Other Drugs (ESPAD). ESPAD Report 2015. Results from the European School Survey Project on Alcohol and Other Drugs. 2016. Available from:. http://www.espad.org/sites/espad.org/files/ESPAD_ report_2015.pdf(Accessed 29 August 2020).
[17]
CSEW. British Crime Survey England and Wales (CSEW). Data tables - Drug Misuse Declared: Findings from the 2010/11 2011. 2011. Available from: . https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/116334/hosb1211-tabs.xls(Accessed 28 August 2020).
[18]
Monshouwer, K.; van der Pol, P.; Drost, Y.C.; van Laar, M.W. Het Grote Uitgaansonderzoek 2016. Trimbos-instituut, Utrecht, The Netherlands. 2016. Available from:. https://www.trimbos.nl/docs/da0f3e40-3ad6-498d-852c-9d59105a85c2.pdf(Accessed 29 August 2020).
[19]
Nabben, T.; Korf, D.J. Drugs in rurale gebieden: GHB-gebruik en - handel op het Nederlandse platteland. Tijdschrift over Cultuur & Criminaliteit, 2016, 6, 59-78..
[20]
Nabben, T.; Luijk, T.; Korf, D.J. Antenne 2017: Trends in alcohol, tabak en drugs bij jonge Amsterdammers; Rozenberg Publishers: Amsterdam, 2018. https://pure.uva.nl/ws/files/42255154/32109 100.pdf
[21]
Palamar, J.J.; Keyes, K.M. Trends in drug use among electronic dance music party attendees in New York City, 2016-2019. Drug Alcohol Depend., 2020, 209 ,107889.
[http://dx.doi.org/10.1016/j.drugalcdep.2020.107889] [PMID: 32050110]
[22]
Achterbergh, R.C.A.; de Vries, H.J.C.; Boyd, A.; Davidovich, U.; Drückler, S.; Hoornenborg, E.; Prins, M.; Matser, A. Identification and characterization of latent classes based on drug use among men who have sex with men at risk of sexually transmitted infections in Amsterdam, the Netherlands. Addiction, 2020, 115(1), 121-133.
[http://dx.doi.org/10.1111/add.14774] [PMID: 31400174]
[23]
Evers, Y.J.; Van Liere, G.A.F.S.; Hoebe, C.J.P.A.; Dukers-Muijrers, N.H.T.M. Chemsex among men who have sex with men living outside major cities and associations with sexually transmitted infections: A cross-sectional study in the Netherlands. PLoS One, 2019, 14(5) ,e0216732.
[http://dx.doi.org/10.1371/journal.pone.0216732] [PMID: 31086390]
[24]
Schmidt, A.J.; Bourne, A.; Weatherburn, P.; Reid, D.; Marcus, U.; Hickson, F. EMIS Network. Illicit drug use among gay and bisexual men in 44 cities: Findings from the European MSM Internet Survey (EMIS). Int. J. Drug Policy, 2016, 38, 4-12.
[http://dx.doi.org/10.1016/j.drugpo.2016.09.007] [PMID: 27788450]
[25]
Hockenhull, J.; Murphy, K.G.; Paterson, S. An observed rise in γ-hydroxybutyrate-associated deaths in London: Evidence to suggest a possible link with concomitant rise in chemsex. Forensic Sci. Int., 2017, 270, 93-97.
[http://dx.doi.org/10.1016/j.forsciint.2016.11.039] [PMID: 27936427]
[26]
Corkery, J.M.; Loi, B.; Claridge, H.; Goodair, C.; Schifano, F. Deaths in the Lesbian, Gay, Bisexual and transgender united kingdom communities associated with GHB and precursors. Curr. Drug Metab., 2018, 19(13), 1086-1099.
[http://dx.doi.org/10.2174/1389200218666171108163817] [PMID: 29119924]
[27]
Busardò, F.P.; Jones, A.W. GHB pharmacology and toxicology: acute intoxication, concentrations in blood and urine in forensic cases and treatment of the withdrawal syndrome. Curr. Neuropharmacol., 2015, 13(1), 47-70.
[http://dx.doi.org/10.2174/1570159X13666141210215423] [PMID: 26074743]
[28]
Hodges, B.; Everett, J. Acute toxicity from home-brewed gamma hydroxybutyrate. J. Am. Board Fam. Pract., 1998, 11(2), 154-157.
[http://dx.doi.org/10.3122/15572625-11-2-154] [PMID: 9542708]
[29]
van Amsterdam, J.G.; van Laar, M.; Brunt, T.M.; van den Brink, W. Risk assessment of gamma-hydroxybutyric acid (GHB) in the Netherlands. Regul. Toxicol. Pharmacol., 2012, 63(1), 55-63.
[http://dx.doi.org/10.1016/j.yrtph.2012.03.005] [PMID: 22440552]
[30]
Erowid, GHB; Dosage, GHB 2011.Available from:. http://www.erowid.org/chemicals/ghb/ghb_dose.shtml(Accessed 22 September 2020).
[31]
Mamelak, M.; Scharf, M.B.; Woods, M. Treatment of narcolepsy with gamma-hydroxybutyrate. A review of clinical and sleep laboratory findings. Sleep, 1986, 9(1 Pt 2), 285-289.
[http://dx.doi.org/10.1093/sleep/9.1.285] [PMID: 3704454]
[32]
Degenhardt, L.; Darke, S.; Dillon, P. The prevalence and correlates of gamma-hydroxybutyrate (GHB) overdose among Australian users. Addiction, 2003, 98(2), 199-204.
[http://dx.doi.org/10.1046/j.1360-0443.2003.00265.x] [PMID: 12534425]
[33]
Miotto, K.; Darakjian, J.; Basch, J.; Murray, S.; Zogg, J.; Rawson, R. Gamma-hydroxybutyric acid: patterns of use, effects and withdrawal. Am. J. Addict., 2001, 10(3), 232-241.
[http://dx.doi.org/10.1080/105504901750532111] [PMID: 11579621]
[34]
Madah-Amiri, D.; Myrmel, L.; Brattebø, G. Intoxication with GHB/GBL: characteristics and trends from ambulance-attended overdoses. Scand. J. Trauma Resusc. Emerg. Med., 2017, 25(1), 98.
[http://dx.doi.org/10.1186/s13049-017-0441-6] [PMID: 28938889]
[35]
Dietze, P.M.; Cvetkovski, S.; Barratt, M.J.; Clemens, S. Patterns and incidence of gamma-hydroxybutyrate (GHB)-related ambulance attendances in Melbourne, Victoria. Med. J. Aust., 2008, 188(12), 709-711.
[http://dx.doi.org/10.5694/j.1326-5377.2008.tb01851.x] [PMID: 18558893]
[36]
Galloway, G.P.; Frederick, S.L.; Staggers, F.E., Jr; Gonzales, M.; Stalcup, S.A.; Smith, D.E. Gamma-hydroxybutyrate: an emerging drug of abuse that causes physical dependence. Addiction, 1997, 92(1), 89-96.
[http://dx.doi.org/10.1111/j.1360-0443.1997.tb03640.x] [PMID: 9060200]
[37]
Gonzalez, A.; Nutt, D.J. Gamma hydroxy butyrate abuse and dependency. J. Psychopharmacol., 2005, 19(2), 195-204.
[http://dx.doi.org/10.1177/0269881105049041] [PMID: 15871147]
[38]
Perez, E.; Chu, J.; Bania, T. Seven days of gamma-hydroxybutyrate (GHB) use produces severe withdrawal. Ann. Emerg. Med., 2006, 48(2), 219-220.
[http://dx.doi.org/10.1016/j.annemergmed.2006.03.040] [PMID: 16857475]
[39]
Grund, J.P.; de Bruin, D.; van Gaalen, S. Going knock-Recurrent comatose GHB intoxication in the Netherlands & Flanders (Belgium). Int. J. Drug Policy, 2018, 58, 137-148.
[http://dx.doi.org/10.1016/j.drugpo.2018.06.010] [PMID: 29957565]
[40]
Degenhardt, L.; Darke, S.; Dillon, P. GHB use among Australians: characteristics, use patterns and associated harm. Drug Alcohol Depend., 2002, 67(1), 89-94.
[http://dx.doi.org/10.1016/S0376-8716(02)00017-0] [PMID: 12062782]
[41]
Stein, L.A.; Lebeau, R.; Clair, M.; Martin, R.; Bryant, M.; Storti, S. Preliminary web-based measures development for GHB: expectancies, functions, and withdrawal. Am. J. Drug Alcohol Abuse, 2012, 38(2), 121-129.
[http://dx.doi.org/10.3109/00952990.2011.643970] [PMID: 22175869]
[42]
Dyer, J.E.; Roth, B.; Hyma, B.A. Gamma-hydroxybutyrate withdrawal syndrome. Ann. Emerg. Med., 2001, 37(2), 147-153.
[http://dx.doi.org/10.1067/mem.2001.112985] [PMID: 11174231]
[43]
van Noorden, M.S.; Kamal, R.; de Jong, C.A.; Vergouwen, A.C.; Zitman, F.G. Gamma-hydroxybutyric acid (GHB) dependence and the GHB withdrawal syndrome: diagnosis and treatment. Ned. Tijdschr. Geneeskd., 2010, 154, A1286.
[PMID: 21040601]
[44]
van Laar, M.; Cruts, G.; van Miltenburg, C.; Strada, L.; Ketelaars, T.; Croes, E.; Beenakkers, E.; Meijer, R. Nationale Drug Monitor.Jaarbericht 2019., 2020.https://www.trimbos.nl/docs/2611d773-620a-45af-a9e5-c27a7e6688e4.pdf
[45]
Wu, Y.; Ali, S.; Ahmadian, G.; Liu, C.C.; Wang, Y.T.; Gibson, K.M.; Calver, A.R.; Francis, J.; Pangalos, M.N.; Carter, S.O. III Gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB receptor (GABABR) binding sites are distinctive from one another: molecular evidence. Neuropharmacology, 2004, 47(8), 1146-1156.
[http://dx.doi.org/10.1016/j.neuropharm.2004.08.019] [PMID: 15567424]
[46]
Crunelli, V.; Emri, Z.; Leresche, N. Unravelling the brain targets of gamma-hydroxybutyric acid. Curr. Opin. Pharmacol., 2006, 6(1), 44-52.
[http://dx.doi.org/10.1016/j.coph.2005.10.001] [PMID: 16368267]
[47]
Brunt, T.M.; van Amsterdam, J.G.; van den Brink, W. GHB, GBL and 1,4-BD addiction. Curr. Pharm. Des., 2014, 20(25), 4076-4085.
[http://dx.doi.org/10.2174/13816128113199990624] [PMID: 24001290]
[48]
Kamal, R.M.; van Noorden, M.S.; Franzek, E.; Dijkstra, B.A.; Loonen, A.J.; De Jong, C.A. The Neurobiological mechanisms of gamma-hydroxybutyrate dependence and withdrawal and their clinical relevance: A Review. Neuropsychobiology, 2016, 73(2), 65-80.
[http://dx.doi.org/10.1159/000443173] [PMID: 27003176]
[49]
Bilotta, F.; Evered, L.A.; Gruenbaum, S.E. Neurotoxicity of anesthetic drugs: an update. Curr. Opin. Anaesthesiol., 2017, 30(4), 452-457.
[http://dx.doi.org/10.1097/ACO.0000000000000482] [PMID: 28562386]
[50]
Kapoor, I.; Prabhakar, H.; Mahajan, C. Postoperative cognitive dysfunction. Indian J. Crit. Care Med., 2019, 23(Suppl. 2), S162-S164.
[http://dx.doi.org/10.5005/jp-journals-10071-23196] [PMID: 31485127]
[51]
Moller, J.T.; Cluitmans, P.; Rasmussen, L.S.; Houx, P.; Rasmussen, H.; Canet, J.; Rabbitt, P.; Jolles, J.; Larsen, K.; Hanning, C.D.; Langeron, O.; Johnson, T.; Lauven, P.M.; Kristensen, P.A.; Biedler, A.; van Beem, H.; Fraidakis, O.; Silverstein, J.H.; Beneken, J.E.; Gravenstein, J.S. International Study of Post-Operative Cognitive Dysfunction. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. Lancet, 1998, 351(9106), 857-861.
[http://dx.doi.org/10.1016/S0140-6736(97)07382-0] [PMID: 9525362]
[52]
Rasmussen, L.S.; Johnson, T.; Kuipers, H.M.; Kristensen, D.; Siersma, V.D.; Vila, P.; Jolles, J.; Papaioannou, A.; Abildstrom, H.; Silverstein, J.H.; Bonal, J.A.; Raeder, J.; Nielsen, I.K.; Korttila, K.; Munoz, L.; Dodds, C.; Hanning, C.D.; Moller, J.T. ISPOCD2(International Study of Postoperative Cognitive Dysfunction) Investigators. Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol. Scand., 2003, 47(3), 260-266.
[http://dx.doi.org/10.1034/j.1399-6576.2003.00057.x] [PMID: 12648190]
[53]
Mason, S.E.; Noel-Storr, A.; Ritchie, C.W. The impact of general and regional anesthesia on the incidence of post-operative cognitive dysfunction and post-operative delirium: a systematic review with meta-analysis. J. Alzheimers Dis., 2010, 22(Suppl. 3), 67-79.
[http://dx.doi.org/10.3233/JAD-2010-101086] [PMID: 20858956]
[54]
Tzimas, P.; Samara, E.; Petrou, A.; Korompilias, A.; Chalkias, A.; Papadopoulos, G. The influence of anesthetic techniques on postoperative cognitive function in elderly patients undergoing hip fracture surgery: General vs spinal anesthesia. Injury, 2018, 49(12), 2221-2226.
[http://dx.doi.org/10.1016/j.injury.2018.09.023] [PMID: 30526923]
[55]
Raposo Pereira, F.; McMaster, M.T.B.; de Vries, Y.A.T.; van den Brink, W.; van Wingen, G.A. Demographic and clinical characteristics of regular GHB-users with and without GHB-induced comas. Subst. Use Misuse, 2020, 55(13), 2148-2155.
[http://dx.doi.org/10.1080/10826084.2020.1793368] [PMID: 32772606]
[56]
van Amsterdam, J.G.; Brunt, T.M.; McMaster, M.T.; Niesink, R.; van Noorden, M.S.; van den Brink, W. Cognitive impairment due to intensive use and overdoses of gammahydroxybutyric acid (GHB). Tijdschr. Psychiatr., 2012, 54(12), 1001-1010.
[PMID: 23250641]
[57]
van Amsterdam, J.G.; Brunt, T.M.; McMaster, M.T.; Niesink, R.J. Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose. Neurosci. Biobehav. Rev., 2012, 36(4), 1217-1227.
[http://dx.doi.org/10.1016/j.neubiorev.2012.02.002] [PMID: 22342779]
[58]
van Amsterdam, J.; Brunt, T.; McMaster, M.; van den Brink, W. Neurotoxicity due to repeated comas following excessive use of gamma-hydroxybutyric acid. Neuropathology of Drug Addictions and Substance Misuse; Elsevier, 2016, pp. 453-459.
[http://dx.doi.org/10.1016/B978-0-12-800212-4.00042-X]
[59]
Liberati, A.; Altman, D.G.; Tetzlaff, J.; Mulrow, C.; Gøtzsche, P.C.; Ioannidis, J.P.; Clarke, M.; Devereaux, P.J.; Kleijnen, J.; Moher, D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ, 2009, 339, b2700.
[http://dx.doi.org/10.1136/bmj.b2700] [PMID: 19622552]
[60]
Sircar, R.; Basak, A. Adolescent gamma-hydroxybutyric acid exposure decreases cortical N-methyl-D-aspartate receptor and impairs spatial learning. Pharmacol. Biochem. Behav., 2004, 79(4), 701-708.
[http://dx.doi.org/10.1016/j.pbb.2004.09.022] [PMID: 15582677]
[61]
Sircar, R.; Basak, A.; Sircar, D.; Wu, L.C. Effects of gamma-hydroxybutyric acid on spatial learning and memory in adolescent and adult female rats. Pharmacol. Biochem. Behav., 2010, 96(2), 187-193.
[http://dx.doi.org/10.1016/j.pbb.2010.04.028] [PMID: 20460135]
[62]
Kueh, D.; Iwamoto, K.; Poling, A.; Baker, L.E. Effects of gamma-hydroxybutyrate (GHB) and its metabolic precursors on delayed-matching-to-position performance in rats. Pharmacol. Biochem. Behav., 2008, 89(2), 179-187.
[http://dx.doi.org/10.1016/j.pbb.2007.12.007] [PMID: 18201754]
[63]
Pedraza, C.; García, F.B.; Navarro, J.F. Neurotoxic effects induced by gammahydroxybutyric acid (GHB) in male rats. Int. J. Neuropsychopharmacol., 2009, 12(9), 1165-1177.
[http://dx.doi.org/10.1017/S1461145709000157] [PMID: 19288974]
[64]
Sircar, R.; Basak, A.; Sircar, D. Gamma-hydroxybutyric acid-induced cognitive deficits in the female adolescent rat. Ann. N. Y. Acad. Sci., 2008, 1139, 386-389.
[http://dx.doi.org/10.1196/annals.1432.044] [PMID: 18991885]
[65]
Ishiwari, K.; Sircar, R. Improvement in γ-hydroxybutyrate-induced contextual fear memory deficit by systemic administration of NCS-382. Neuroreport, 2016, 27(9), 627-631.
[http://dx.doi.org/10.1097/WNR.0000000000000586] [PMID: 27105320]
[66]
van Nieuwenhuijzen, P.S.; Long, L.E.; Hunt, G.E.; Arnold, J.C.; McGregor, I.S. Residual social, memory and oxytocin-related changes in rats following repeated exposure to γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination. Psychopharmacology (Berl.), 2010, 212(4), 663-674.
[http://dx.doi.org/10.1007/s00213-010-1986-5] [PMID: 20730418]
[67]
Johansson, J.; Grönbladh, A.; Hallberg, M. Gamma-hydroxybutyrate (GHB) induces cognitive deficits and affects GABAB receptors and IGF-1 receptors in male rats. Behav. Brain Res., 2014, 269, 164-174.
[http://dx.doi.org/10.1016/j.bbr.2014.04.034] [PMID: 24786330]
[68]
Sherry, J.M.; Hazi, A.; Hale, M.W.; Milsome, S.L.; Crowe, S.F. Gamma-butyrolactone (GBL) disruption of passive avoidance learning in the day-old chick appears to be due to its effect on GABAB not gamma-hydroxybutyric acid (GHB) receptors. Behav. Brain Res., 2009, 197(2), 347-355.
[http://dx.doi.org/10.1016/j.bbr.2008.09.024] [PMID: 18948143]
[69]
Smith, M.A.; Gergans, S.R.; Lyle, M.A. The motor-impairing effects of GABA(A) and GABA(B) agonists in gamma-hydroxybutyrate (GHB)-treated rats: cross-tolerance to baclofen but not flunitrazepam. Eur. J. Pharmacol., 2006, 552(1-3), 83-89.
[http://dx.doi.org/10.1016/j.ejphar.2006.08.080] [PMID: 17026996]
[70]
van Nieuwenhuijzen, P.S.; McGregor, I.S.; Chebib, M.; Hunt, G.E. Regional Fos-expression induced by γ-hydroxybutyrate (GHB): comparison with γ-butyrolactone (GBL) and effects of co-administration of the GABAB antagonist SCH 50911 and putative GHB antagonist NCS-382. Neuroscience, 2014, 277, 700-715.
[http://dx.doi.org/10.1016/j.neuroscience.2014.07.056] [PMID: 25088910]
[71]
Sircar, R.; Wu, L.C.; Reddy, K.; Sircar, D.; Basak, A.K. GHB-induced cognitive deficits during adolescence and the role of NMDA receptor. Curr. Neuropharmacol., 2011, 9(1), 240-243.
[http://dx.doi.org/10.2174/157015911795017038] [PMID: 21886597]
[72]
Castelli, M.P.; Ferraro, L.; Mocci, I.; Carta, F.; Carai, M.A.; Antonelli, T.; Tanganelli, S.; Cignarella, G.; Gessa, G.L. Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of gamma-hydroxybutyric acid. J. Neurochem., 2003, 87(3), 722-732.
[http://dx.doi.org/10.1046/j.1471-4159.2003.02037.x] [PMID: 14535954]
[73]
Quang, L.S.; Desai, M.C.; Kraner, J.C.; Shannon, M.W.; Woolf, A.D.; Maher, T.J. Enzyme and receptor antagonists for preventing toxicity from the gamma-hydroxybutyric acid precursor 1,4-butanediol in CD-1 mice. Ann. N. Y. Acad. Sci., 2002, 965, 461-472.
[http://dx.doi.org/10.1111/j.1749-6632.2002.tb04187.x] [PMID: 12105121]
[74]
Brolin, E.; Johansson, J.; Zelleroth, S.; Diwakarla, S.; Nyberg, F.; Grönbladh, A.; Hallberg, M. The mRNA expression of insulin-like growth factor-1 (Igf1) is decreased in the rat frontal cortex following gamma-hydroxybutyrate (GHB) administration. Neurosci. Lett., 2017, 646, 15-20.
[http://dx.doi.org/10.1016/j.neulet.2017.02.053] [PMID: 28249788]
[75]
Klein, C.; Kemmel, V.; Taleb, O.; Aunis, D.; Maitre, M. Pharmacological doses of gamma-hydroxybutyrate (GHB) potentiate histone acetylation in the rat brain by histone deacetylase inhibition. Neuropharmacology, 2009, 57(2), 137-147.
[http://dx.doi.org/10.1016/j.neuropharm.2009.04.013] [PMID: 19427877]
[76]
Maitre, M.; Klein, C.; Mensah-Nyagan, A.G. Mechanisms for the specific properties of γ-hydroxybutyrate in brain. Med. Res. Rev., 2016, 36(3), 363-388.
[http://dx.doi.org/10.1002/med.21382] [PMID: 26739481]
[77]
Sgaravatti, A.M.; Sgarbi, M.B.; Testa, C.G.; Durigon, K.; Pederzolli, C.D.; Prestes, C.C.; Wyse, A.T.; Wannmacher, C.M.; Wajner, M.; Dutra-Filho, C.S. Gamma-hydroxybutyric acid induces oxidative stress in cerebral cortex of young rats. Neurochem. Int., 2007, 50(3), 564-570.
[http://dx.doi.org/10.1016/j.neuint.2006.11.007] [PMID: 17197055]
[78]
Schnackenberg, B.J.; Saini, U.T.; Robinson, B.L.; Ali, S.F.; Patterson, T.A. An acute dose of gamma-hydroxybutyric acid alters gene expression in multiple mouse brain regions. Neuroscience, 2010, 170(2), 523-541.
[http://dx.doi.org/10.1016/j.neuroscience.2010.06.049] [PMID: 20654702]
[79]
van Nieuwenhuijzen, P.S.; Kashem, M.A.; Matsumoto, I.; Hunt, G.E.; McGregor, I.S. A long hangover from party drugs: residual proteomic changes in the hippocampus of rats 8 weeks after γ-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination. Neurochem. Int., 2010, 56(8), 871-877.
[http://dx.doi.org/10.1016/j.neuint.2010.03.002] [PMID: 20227452]
[80]
Ottani, A.; Saltini, S.; Bartiromo, M.; Zaffe, D.; Renzo Botticelli, A.; Ferrari, A.; Bertolini, A.; Genedani, S. Effect of gamma-hydroxybutyrate in two rat models of focal cerebral damage. Brain Res., 2003, 986(1-2), 181-190.
[http://dx.doi.org/10.1016/S0006-8993(03)03252-9] [PMID: 12965243]
[81]
Ottani, A.; Vergoni, A.V.; Saltini, S.; Mioni, C.; Giuliani, D.; Bartiromo, M.; Zaffe, D.; Botticelli, A.R.; Ferrari, A.; Bertolini, A.; Genedani, S. Effect of late treatment with gamma-hydroxybutyrate on the histological and behavioral consequences of transient brain ischemia in the rat. Eur. J. Pharmacol., 2004, 485(1-3), 183-191.
[http://dx.doi.org/10.1016/j.ejphar.2003.11.072] [PMID: 14757139]
[82]
Gao, B.; Kilic, E.; Baumann, C.R.; Hermann, D.M.; Bassetti, C.L. Gamma-hydroxybutyrate accelerates functional recovery after focal cerebral ischemia. Cerebrovasc. Dis., 2008, 26(4), 413-419.
[http://dx.doi.org/10.1159/000151683] [PMID: 18753748]
[83]
Laraway, S.; Snycerski, S.; Baker, L.E.; Poling, A. Gamma-hydroxybutyrate (GHB) reduces operant behavior without impairing working memory in rats responding under fixed-consecutive-number schedules. Pharmacol. Biochem. Behav., 2008, 88(3), 205-212.
[http://dx.doi.org/10.1016/j.pbb.2007.08.002] [PMID: 17904624]
[84]
Nakamura, R.K.; Myslobodsky, M.S.; Coppola, R.; Johannesen-Conway, J.; Mirsky, A.F. Effects of gamma-hydroxybutyrate on the performance of monkeys in a Go/No-go visual discrimination task. Behav. Brain Res., 1987, 26(1), 19-27.
[http://dx.doi.org/10.1016/0166-4328(87)90012-X] [PMID: 3675831]
[85]
NHS. National Health Service (NHS). New medicine recommendation. Sodium oxybate oral solution 500 mg/ml (Xyrem®) for treatment of narcolepsy with cataplexy., . 2016.
[86]
Jazz Pharmaceuticals. Xyrem. Full prescribing information. 2020. Available from:. https://pp.jazzpharma.com/pi/xyrem.en.USPI.pdf(Accessed 29 August 2020)
[87]
Barker, J.C.; Karsoho, H. Hazardous use of gamma hydroxybutyrate: driving under the influence. Subst. Use Misuse, 2008, 43(11), 1507-1520.
[http://dx.doi.org/10.1080/10826080802237928] [PMID: 18752156]
[88]
Smith, K.M. Drugs used in acquaintance rape. J. Am. Pharm. Assoc. (Wash), 1999, 39, 519-525.
[89]
Schwartz, R.H.; Milteer, R.; LeBeau, M.A. Drug-facilitated sexual assault (‘date rape’). South. Med. J., 2000, 93(6), 558-561.
[http://dx.doi.org/10.1097/00007611-200093060-00002] [PMID: 10881768]
[90]
Varela, M.; Nogué, S.; Orós, M.; Miró, O. Gamma hydroxybutirate use for sexual assault. Emerg. Med. J., 2004, 21(2), 255-256.
[http://dx.doi.org/10.1136/emj.2002.002402] [PMID: 14988371]
[91]
Abanades, S.; Farré, M.; Segura, M.; Pichini, S.; Barral, D.; Pacifici, R.; Pellegrini, M.; Fonseca, F.; Langohr, K.; De La Torre, R. Gamma-hydroxybutyrate (GHB) in humans: pharmacodynamics and pharmacokinetics. Ann. N. Y. Acad. Sci., 2006, 1074, 559-576.
[http://dx.doi.org/10.1196/annals.1369.065] [PMID: 17105953]
[92]
Abanades, S.; Farré, M.; Barral, D.; Torrens, M.; Closas, N.; Langohr, K.; Pastor, A.; de la Torre, R. Relative abuse liability of gamma-hydroxybutyric acid, flunitrazepam, and ethanol in club drug users. J. Clin. Psychopharmacol., 2007, 27(6), 625-638.
[http://dx.doi.org/10.1097/jcp.0b013e31815a2542] [PMID: 18004131]
[93]
Bosch, O.G.; Eisenegger, C.; Gertsch, J.; von Rotz, R.; Dornbierer, D.; Gachet, M.S.; Heinrichs, M.; Wetter, T.C.; Seifritz, E.; Quednow, B.B. Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone. Psychoneuroendocrinology, 2015, 62, 1-10.
[http://dx.doi.org/10.1016/j.psyneuen.2015.07.167] [PMID: 26209926]
[94]
Carter, L.P.; Richards, B.D.; Mintzer, M.Z.; Griffiths, R.R. Relative abuse liability of GHB in humans: A comparison of psychomotor, subjective, and cognitive effects of supratherapeutic doses of triazolam, pentobarbital, and GHB. Neuropsychopharmacology, 2006, 31(11), 2537-2551.
[http://dx.doi.org/10.1038/sj.npp.1301146] [PMID: 16880774]
[95]
Carter, L.P.; Griffiths, R.R.; Mintzer, M.Z. Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteers. Psychopharmacology (Berl.), 2009, 206(1), 141-154.
[http://dx.doi.org/10.1007/s00213-009-1589-1] [PMID: 19543883]
[96]
Dornbierer, D.A.; Kometer, M.; Von Rotz, R.; Studerus, E.; Gertsch, J.; Gachet, M.S.; Vollenweider, F.X.; Seifritz, E.; Bosch, O.G.; Quednow, B.B. Effects of gamma-hydroxybutyrate on neurophysiological correlates of performance and conflict monitoring. Eur. Neuropsychopharmacol., 2019, 29(4), 539-548.
[http://dx.doi.org/10.1016/j.euroneuro.2019.02.004] [PMID: 30824339]
[97]
Ferrara, S.D.; Giorgetti, R.; Zancaner, S.; Orlando, R.; Tagliabracci, A.; Cavarzeran, F.; Palatini, P. Effects of single dose of gamma-hydroxybutyric acid and lorazepam on psychomotor performance and subjective feelings in healthy volunteers. Eur. J. Clin. Pharmacol., 1999, 54(11), 821-827.
[http://dx.doi.org/10.1007/s002280050560] [PMID: 10027654]
[98]
Grove-White, I.G.; Kelman, G.R. Critical flicker frequency after small doses of methohexitone, diazepam and sodium 4-hydroxybutyrate. Br. J. Anaesth., 1971, 43(2), 110-112.
[http://dx.doi.org/10.1093/bja/43.2.110] [PMID: 5550840]
[99]
Grove-White, I.G.; Kelman, G.R. Effect of methohexitone, diazepam and sodium 4-hydroxybutyrate on short-term memory. Br. J. Anaesth., 1971, 43(2), 113-116.
[http://dx.doi.org/10.1093/bja/43.2.113] [PMID: 5550841]
[100]
Johnson, M.W.; Griffiths, R.R. Comparative abuse liability of GHB and ethanol in humans. Exp. Clin. Psychopharmacol., 2013, 21(2), 112-123.
[http://dx.doi.org/10.1037/a0031692] [PMID: 23421353]
[101]
Mattila, M.J.; Palva, E.; Seppälä, T.; Ostrovskaya, R.U. Actions and interactions with alcohol of drugs on psychomotor skills: comparison of diazepam and gamma-hydroxybutyric acid. Arch. Int. Pharmacodyn. Ther., 1978, 234(2), 236-246.
[PMID: 708150]
[102]
Mednick, S.C.; McDevitt, E.A.; Walsh, J.K.; Wamsley, E.; Paulus, M.; Kanady, J.C.; Drummond, S.P. The critical role of sleep spindles in hippocampal-dependent memory: a pharmacology study. J. Neurosci., 2013, 33(10), 4494-4504.
[http://dx.doi.org/10.1523/JNEUROSCI.3127-12.2013] [PMID: 23467365]
[103]
Pross, N.; Patat, A.; Vivet, P.; Bidaut, M.; Fauchoux, N. Pharmacodynamic interactions of a solid formulation of sodium oxybate and ethanol in healthy volunteers. Br. J. Clin. Pharmacol., 2015, 80(3), 480-492.
[http://dx.doi.org/10.1111/bcp.12632] [PMID: 25782469]
[104]
Vienne, J.; Lecciso, G.; Constantinescu, I.; Schwartz, S.; Franken, P.; Heinzer, R.; Tafti, M. Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory. Sleep (Basel), 2012, 35(8), 1071-1083.
[http://dx.doi.org/10.5665/sleep.1992] [PMID: 22851803]
[105]
Mintzer, M.Z.; Griffiths, R.R. Alcohol and triazolam: differential effects on memory, psychomotor performance and subjective ratings of effects. Behav. Pharmacol., 2002, 13(8), 653-658.
[http://dx.doi.org/10.1097/00008877-200212000-00007] [PMID: 12478216]
[106]
Raposo, P.F.; McMaster, M.T.B.; de Vries, Y.D.A.T.; Polderman, N.; van den Brink, W.; van Wingen, G.A. Influence of gamma-hydroxybutyric acid-use and gamma-hydroxybutyric acid-induced coma on affect and the affective network. Eur. Addict. Res., 2019, 25(4), 173-181.
[http://dx.doi.org/10.1159/000497381] [PMID: 30999293]
[107]
Raposo, P.F.; McMaster, M.T.B.; Polderman, N.; de Vries, Y.D.A.T.; van den Brink, W.; van Wingen, G.A. Effect of GHB-use and GHB-induced comas on dorsolateral prefrontal cortex functioning in humans. Neuroimage Clin., 2018, 20, 923-930.
[http://dx.doi.org/10.1016/j.nicl.2018.09.022] [PMID: 30308378]
[108]
Raposo, P.F.; McMaster, M.T.B.; Polderman, N.; de Vries, Y.D.A.T.; van den Brink, W.; van Wingen, G.A. Adverse effects of GHB-induced coma on long-term memory and related brain function. Drug Alcohol Depend., 2018, 190, 29-36.
[http://dx.doi.org/10.1016/j.drugalcdep.2018.05.019] [PMID: 29966850]
[109]
Raposo Pereira, F.; McMaster, M.T.B.; Schellekens, A.; Polderman, N.; de Vries, Y.D.A.T.; van den Brink, W.; van Wingen, G.A. Effects of Recreational GHB use and multiple ghb-induced comas on brain structure and impulsivity. Front. Psychiatry, 2020, 11, 166.
[http://dx.doi.org/10.3389/fpsyt.2020.00166] [PMID: 32300311]
[110]
Raposo Pereira, F.; Zhutovsky, P.; Mcmaster, M.T.B.; Polderman, N.; de Vries, Y.D.A.T.; van den Brink, W.; van Wingen, G.A. Recreational use of GHB is associated with alterations of resting state functional connectivity of the central executive and default mode networks. Hum. Brain Mapp., 2019, 40(8), 2413-2421.
[http://dx.doi.org/10.1002/hbm.24532] [PMID: 30720906]
[111]
Belrose, J.C.; Noppens, R.R. Anesthesiology and cognitive impairment: a narrative review of current clinical literature. BMC Anesthesiol., 2019, 19(1), 241.
[http://dx.doi.org/10.1186/s12871-019-0903-7] [PMID: 31881996]
[112]
Cottrell, J.E.; Hartung, J. Anesthesia and cognitive outcome in elderly patients: a narrative viewpoint. J. Neurosurg. Anesthesiol., 2020, 32(1), 9-17.
[http://dx.doi.org/10.1097/ANA.0000000000000640] [PMID: 31490337]
[113]
Squire, L.R.; Stark, C.E.; Clark, R.E. The medial temporal lobe. Annu. Rev. Neurosci., 2004, 27, 279-306.
[http://dx.doi.org/10.1146/annurev.neuro.27.070203.144130] [PMID: 15217334]
[114]
Kemmel, V.; Klein, C.; Dembélé, D.; Jost, B.; Taleb, O.; Aunis, D.; Mensah-Nyagan, A.G.; Maitre, M. A single acute pharmacological dose of γ-hydroxybutyrate modifies multiple gene expression patterns in rat hippocampus and frontal cortex. Physiol. Genomics, 2010, 41(2), 146-160.
[http://dx.doi.org/10.1152/physiolgenomics.00208.2009] [PMID: 20103696]
[115]
Sgaravatti, A.M.; Magnusson, A.S.; Oliveira, A.S.; Mescka, C.P.; Zanin, F.; Sgarbi, M.B.; Pederzolli, C.D.; Wyse, A.T.; Wannmacher, C.M.; Wajner, M.; Dutra-Filho, C.S. Effects of 1,4-butanediol administration on oxidative stress in rat brain: Study of the neurotoxicity of gamma-hydroxybutyric acid in vivo. Metab. Brain Dis., 2009, 24(2), 271-282.
[http://dx.doi.org/10.1007/s11011-009-9136-7] [PMID: 19296210]
[116]
Jevtovic-Todorovic, V. General anesthetics and neurotoxicity: How much do we know? Anesthesiol. Clin., 2016, 34(3), 439-451.
[http://dx.doi.org/10.1016/j.anclin.2016.04.001] [PMID: 27521190]
[117]
Busl, K.M.; Greer, D.M. Hypoxic-ischemic brain injury: pathophysiology, neuropathology and mechanisms. NeuroRehabilitation, 2010, 26(1), 5-13.
[http://dx.doi.org/10.3233/NRE-2010-0531] [PMID: 20130351]
[118]
Caine, D.; Watson, J.D. Neuropsychological and neuropathological sequelae of cerebral anoxia: a critical review. J. Int. Neuropsychol. Soc., 2000, 6(1), 86-99.
[http://dx.doi.org/10.1017/S1355617700611116] [PMID: 10761372]
[119]
Perouansky, M.; Hemmings, H.C., Jr; Riou, B. Neurotoxicity of general anesthetics: cause for concern? Anesthesiology, 2009, 111(6), 1365-1371.
[http://dx.doi.org/10.1097/ALN.0b013e3181bf1d61] [PMID: 19934883]
[120]
Nayak, C.; Nayak, D.; Raja, A.; Rao, A. Time-level relationship between indicators of oxidative stress and Glasgow Coma Scale scores of severe head injury patients. Clin. Chem. Lab. Med., 2006, 44(4), 460-463.
[http://dx.doi.org/10.1515/CCLM.2006.068] [PMID: 16599841]
[121]
Snyder, B.; Shell, B.; Cunningham, J.T.; Cunningham, R.L. Chronic intermittent hypoxia induces oxidative stress and inflammation in brain regions associated with early-stage neurodegeneration. Physiol. Rep., 2017, 5(9), 5.
[http://dx.doi.org/10.14814/phy2.13258] [PMID: 28473320]
[122]
FDA. Food and Drug Administration (FDA) Approved labeling text dated 11/18/05. NDA 21-196/S-005. 2005. Available from:. https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021196s005lbl.pdf Accessed 28 August 2020
[123]
Wang, Y.G.; Swick, T.J.; Carter, L.P.; Thorpy, M.J.; Benowitz, N.L. Safety overview of postmarketing and clinical experience of sodium oxybate (Xyrem): abuse, misuse, dependence, and diversion. J. Clin. Sleep Med., 2009, 5(4), 365-371.
[http://dx.doi.org/10.5664/jcsm.27549] [PMID: 19968016]

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