Genetic Variation and Atherosclerosis

Erik      Biros; Mirko      Karan; Jonathan      Golledge

Abstract

A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk factors, such as plasma lipoprotein levels, inflammation and vascular calcification. This review presents examples of present studies of the role of genetic polymorphism in atherosclerosis.

Keywords: Atherosclerosis, genetic polymorphism, risk factors

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