Developing a Standardized Review Process of Pharmacogenomics Resources for Psychotropic Medications

Title:Developing a Standardized Review Process of Pharmacogenomics Resources for Psychotropic Medications

Volume: 18 Issue: 1

Author(s): Maja Stoneberg*, Natasha Petry, Carlina Grindeland, Monte Roemmich, Amanda Massmann, Jordan Baye and April Schultz

Affiliation:

• Department of Pharmacy, Sanford Health Fargo, Fargo, ND58104,United States

Keywords: Pharmacogenomics, Clinical Decision Support (CDS), primary literature, standardized review, drug-gene monographs, psychotropic.

Abstract:

Background: The impact of personalized medicine is potentially enormous, but the genetic results are often difficult to integrate into health settings. A number of research studies are emerging to aid in translating pharmacogenomics into clinical practice.

Objective: We aimed to create a standardized process to guide the implementation of dose adjustment recommendations into the electronic health record (EHR).

Materials and Methods: Monographs were created for selected drug-gene pairs, allowing for a standardized review of available evidence. A scoring template was developed to assess whether the evidence presented in the drug monograph qualified the mentioned drug-gene pair for Clinical Decision Support (CDS) within the EHR.

Results: Of nine medications reviewed, only one drug-gene pair qualified for a CDS proposal to the institution’s governing pharmacogenomics committee.

Conclusion: This project resulted in the development of a standard process for reviewing pharmacogenomics- related literature, allowing for more CDS proposals to be accepted.

Cite this article as:

Stoneberg Maja *, Petry Natasha , Grindeland Carlina , Roemmich Monte , Massmann Amanda , Baye Jordan and Schultz April , Developing a Standardized Review Process of Pharmacogenomics Resources for Psychotropic Medications, Current Pharmacogenomics and Personalized Medicine 2021; 18 (1) . https://dx.doi.org/10.2174/1875692118666210603155248