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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Amino Acid Derived Prodrugs: An Approach to Improve the Bioavailability of Clinically Approved Drugs

Author(s): Yogesh Singh, Samriti Saklani, Tanmoy Tantra and Suresh Thareja*

Volume 21 , Issue 24 , 2021

Published on: 24 August, 2021

Page: [2170 - 2183] Pages: 14

DOI: 10.2174/1568026621666210602154438

Price: $65


Amino acids derived prodrugs emerged as an attractive approach to improve oral delivery of drugs with low solubility and permeability. Conjugation of amino acids with parent drug molecules resulted in several-fold increases in water solubility. Acceptability of the amino acids derived prodrug approach increases day by day to fulfill the different characteristics needed to get the desired pharmacological or therapeutic activity. Due to the significant structural diversity of amino acids, various amino acids can be employed as a carrier to provide desirable Pharmacokinetic-Pharmacodynamic (PK-PD) characteristics. The present review focused on using amino acids as a carrier moiety to improve approved drugs' bioavailability. Attempts have been made to cover amino acid conjugated clinically available drugs.

Keywords: Amino acid, Prodrug, PK, PD, Bioavailability, Solubility, ADR.

Graphical Abstract

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