Generic placeholder image

Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Imidazole Scaffold Based Compounds in the Development of Therapeutic Drugs

Author(s): Fanjie Hu, Lina Zhang, Kutty Selva Nandakumar and Kui Cheng*

Volume 21 , Issue 28 , 2021

Page: [2514 - 2528] Pages: 15

DOI: 10.2174/1568026621666210527103225

Price: $65

Abstract

Imidazole has an important five-membered aromatic heterocyclic ring, which is available widely in natural products and synthetic molecules. The special structural characteristics of imidazole ring enable it to bind with a variety of enzymes and receptors through hydrogen bonds, coordination, ion-dipole and cation-π interactions, hydrophobic effects, and Van der Waals forces. These interactions promote several biological activities involving anti-tumor, anti-inflammatory, anti-microbial, and anti-viral properties. Herein, we review and discuss recent developments in using imidazole derivatives and their special pharmacological activities for the treatment of various diseases.

Keywords: Imidazole derivatives, Antitumor, Anti-inflammatory, Anti-microbial, Antiviral, Therapeutic drugs.

Graphical Abstract

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy