Abstract
Aim/ Objective: Phytochemicals are considered an ideal candidate for the production of anticancer drugs due to their pleiotropic activity on multi-mode target events.
Materials and Methods: Plants are ideal reservoirs for new chemical entities and provide a promising cancer research line. Cancer cells can be formed through different types of mutations, including Point mutation, DNA amplification, chromosomal rearrangement, Epigenetic mutation.
Results and Discussion: Products derived from plants are a groundbreaking area because they are eco-friendly, low-cost, Easy, simple, safer, and less toxic compared to other methods of treatment. Vincristine, vinblastine, paclitaxel, camptothecin, cryptolepine, and its analogues, berberine, Antofine, curcumin, ginsenoside, fisetin, chelerythrine, chelidonine, clivorine, clathrodin, dibromophakellstatin, etc are some potential phytochemicals.
Conclusion: The review provides in-depth details of structure, properties, mechanism of action and potential anti-cancer activity of phytochemicals derived from plant sources.
Keywords: Cancer, phytoconstituents, alkaloid, isoquinoline, phenanthroindolizidine, anticancer drugs.
Current Traditional Medicine
Title:Biologically Active Phytochemicals: A Brief Appraisal
Volume: 7 Issue: 6
Author(s): Ayush Mahajan, Pulkit Rana, Dilpreet Singh*Kuldeep Singh
Affiliation:
- Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab,India
Keywords: Cancer, phytoconstituents, alkaloid, isoquinoline, phenanthroindolizidine, anticancer drugs.
Abstract: Aim/ Objective: Phytochemicals are considered an ideal candidate for the production of anticancer drugs due to their pleiotropic activity on multi-mode target events.
Materials and Methods: Plants are ideal reservoirs for new chemical entities and provide a promising cancer research line. Cancer cells can be formed through different types of mutations, including Point mutation, DNA amplification, chromosomal rearrangement, Epigenetic mutation.
Results and Discussion: Products derived from plants are a groundbreaking area because they are eco-friendly, low-cost, Easy, simple, safer, and less toxic compared to other methods of treatment. Vincristine, vinblastine, paclitaxel, camptothecin, cryptolepine, and its analogues, berberine, Antofine, curcumin, ginsenoside, fisetin, chelerythrine, chelidonine, clivorine, clathrodin, dibromophakellstatin, etc are some potential phytochemicals.
Conclusion: The review provides in-depth details of structure, properties, mechanism of action and potential anti-cancer activity of phytochemicals derived from plant sources.
Export Options
About this article
Cite this article as:
Mahajan Ayush , Rana Pulkit, Singh Dilpreet *, Singh Kuldeep , Biologically Active Phytochemicals: A Brief Appraisal, Current Traditional Medicine 2021; 7 (6) : e270521193631 . https://dx.doi.org/10.2174/2215083807666210527094408
DOI https://dx.doi.org/10.2174/2215083807666210527094408 |
Print ISSN 2215-0838 |
Publisher Name Bentham Science Publisher |
Online ISSN 2215-0846 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Imaging with Raman Spectroscopy
Current Pharmaceutical Biotechnology Contribution of Platelet-Derived CD40 Ligand to Inflammation, Thrombosis and Neoangiogenesis
Current Medicinal Chemistry The Holy Grail of Polymer Therapeutics for Cancer Therapy: An Overview on the Pharmacokinetics and Bio Distribution
Current Drug Metabolism Recent Clinical Trials of mTOR-Targeted Cancer Therapies
Reviews on Recent Clinical Trials Multi-Modal Imaging and Cancer Therapy Using Lanthanide Oxide Nanoparticles: Current Status and Perspectives
Current Medicinal Chemistry Cancer Pharmacogenomics: Germline DNA, Tumor DNA, or Both?
Current Pharmacogenomics Towards Understanding the Roles of Prohibitins, Multi-Functional Regulator Proteins
Current Chemical Biology Small Molecules with EGFR-TK Inhibitor Activity
Current Drug Targets AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species
Current Pharmaceutical Design Peroxisome Proliferator-Activated Receptors: Role of Isoform Gamma in the Antineoplastic Effect of Iodine in Mammary Cancer
Current Cancer Drug Targets Epidermal Growth Factor Receptor Inhibitors: A New Prospective in the Treatment of Lung Cancer
Current Medicinal Chemistry - Anti-Cancer Agents Targeting of Peptide Cytotoxins to LHRH Receptors For Treatment of Cancer
Current Drug Targets Chitosan Nanoparticles for Melanoma Cancer Treatment by Photodynamic Therapy and Electrochemotherapy Using Aminolevulinic Acid Derivatives
Current Medicinal Chemistry Subject Index To Volume 2
Current Women`s Health Reviews Oral Precancerous Lesions Show Increased Levels of Glutathione Compared to Cancerous Tissue
Current Nutrition & Food Science Management of Antineutrophil Cytoplasmic Antibody Associated Vasculitis
Current Immunology Reviews (Discontinued) Role of mTOR in Hematological Malignancies
Current Cancer Therapy Reviews The Interaction of Histone Deacetylase Inhibitors and DNA Methyltransferase Inhibitors in the Treatment of Human Cancer Cells
Current Medicinal Chemistry - Anti-Cancer Agents Recent Progress on Apoptotic Activity of Triazoles
Current Drug Targets PET Designated Flouride-18 Production and Chemistry
Current Topics in Medicinal Chemistry