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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Small-Molecule Inhibitors Targeting eIF4A in Leukemia

Author(s): Xiaofeng Jia and Hong Zhou*

Volume 22 , Issue 7 , 2021

Published on: 26 May, 2021

Page: [559 - 566] Pages: 8

DOI: 10.2174/1389203722666210526155808

Price: $65

Abstract

Eukaryotic translation initiation factor 4A (eIF4A) is a highly conserved DEAD-box RNA helicase in eukaryotes with ATPase and RNA helicase activities. eIF4A plays an important role in capdependent translation at the initiation of mRNA translation, and carcinoma signal transduction pathways are focused on cap-dependent translation. eIF4A is highly expressed in a variety of cancers, and its high expression is associated with the degree of leukemia progression. Therefore, eIF4A, as a target for tumor therapy, has become a hot research topic. Many small-molecule inhibitors targeting eIF4A have been demonstrated in preclinical cancer model trials. The purpose of this review is to describe the function of eIF4A and the development of eIF4A targeting inhibitors.

Keywords: eIF4A, eIF4A inhibitors, leukemia, prognosis, therapeutic target, ATPase.

Graphical Abstract

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