Abstract
The investigation of effective and green synthetic routes to approach to novel fused heterocycles with pyridopyrimidine and pyridopyrazine scaffolds stirs up broad interest from scientists as they are capable of providing valuable properties such as anticancer and antimicrobial activities and they are proved γ-secretase modulators, polymers, and corrosion inhibitors. This causes a steady increase in the number of publications on titled condensed systems. The present review article summarizes recent literature data from 2010 to 2020 on the methods of synthesis, chemical transformations and biological properties of condensed bicyclic systems of pyridopyrimidine and pyridopyrazine with a bridgehead nitrogen atom to establish the current state of the art in this area.
Keywords: Pyrido[1, 2-a]pyrimidines, pyrido[1, 2-a]pyrazines, pyrido[1, 2-c]pyrimidines, bridgehead nitrogen atom, reactivity, biological activity.
Graphical Abstract
Call for Papers in Thematic Issues
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Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
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