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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Thiazolidinedione: A Privileged Scaffold for the Development of Anticancer Agents

Author(s): Juan Sun, Yue-Hu Chen, Han-Yu Liu, Emmerson Hondo, Yang Zhou* and Yuan-Feng Wu*

Volume 21, Issue 28, 2021

Published on: 31 May, 2021

Page: [2529 - 2545] Pages: 17

DOI: 10.2174/1568026621666210521143550

Price: $65


Thiazolidinedione, an important heterocyclic ring system, is a pharmacophore and a privileged scaffold in medicinal chemistry. Researchers have shown its potential application as a backbone for inhibitors, as it is involved in anticancer development strategies, cancer progression and metastasis. In this paper, the anticancer activities of thiazolidinedione derivatives were reviewed for the first time with respect to different substituents and their positions. This work may imitate a stirring wheel to guide further advanced development of new anticancer molecules with high efficacy.

Keywords: Thiazolidinedione, Anticancer, Structure-activity relationship, 3D-QSAR, Inhibitors, Molecular Docking.

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