Recent Advances in Synthesis and Reactions of β-Amino-α ,β -Enones (Enaminones)

Title:Recent Advances in Synthesis and Reactions of β-Amino-α ,β -Enones (Enaminones)

Volume: 18 Issue: 7

Author(s): Thoraya Farghaly*, Alaa M. Abo Alnaja and Mohamed R. Shaaban*

Affiliation:

• Department of Chemistry, Faculty of Science, Cairo University, Giza 12613,Egypt

• Department of Chemistry, Faculty of Science, Cairo University, Giza 12613,Egypt

Keywords: Enaminones, nitrogen nucleophiles, heterocycles, synthesis, β-enamino, β-amino-α, β-enones.

Abstract: β-Amino-α,β-enones or β-enamino carbonyl compounds are versatile synthons intermediates for the construction of various bio-active heterocyclic compounds and have been established as multipurpose synthetic precursors in organic syntheses and in pharmaceutical developments. In this work, we will discuss the different synthetic routes to obtain β−amino−α,β-enones or β-enamino carbonyl compounds, their reactions, and their utility in the construction of organic frameworks and heterocyclic ring systems. Structurally, β- amino-α,β-enones are attractive intermediates that syndicate the ambident behaviours of nucleophilicity and electrophilicity of enones at the same time. β-amino-α,β-enones have been known as acceptors in both 1,2- and 1,4- additions that make them good intermediate compounds for annulation to different heterocycles.

Cite this article as:

Farghaly Thoraya *, Abo Alnaja M. Alaa and Shaaban R. Mohamed *, Recent Advances in Synthesis and Reactions of β-Amino-α ,β -Enones (Enaminones), Current Organic Synthesis 2021; 18 (7) . https://dx.doi.org/10.2174/1570179418666210512015725