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Current Neuropharmacology

Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

General Review Article

Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources

Author(s): Abdul Jalil Shah, Reyaz Hassan Mir , Roohi Mohi-ud-din *, Faheem Hyder Pottoo, Mubashir Hussain Masoodi* and Zulfiqar Ali Bhat*

Volume 19 , Issue 11 , 2021

Published on: 26 April, 2021

Page: [2020 - 2037] Pages: 18

DOI: 10.2174/1570159X19666210426115234

Price: $65

Abstract

Depression, a well-known mental disorder, has global prevalence, affecting nearly 17% of the population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural products, their derivatives, and their analogs are the main sources for new drug candidates of depression. The mechanisms include interplay with γ-aminobutyric acid (GABA) receptors, serotonergic, dopaminergic noradrenergic systems, and elevation of BDNF levels. The focus of this article is to review the role of signalling molecules in depression and highlight the use of plant-derived natural compounds to counter CNS depression.

Keywords: Antidepressants, plant-derived natural compounds, CNS, neurotransmitters, BDNF, monoamines.

Graphical Abstract

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