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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Perspective Article

Does Human Alpha-Synuclein Behave Like Prions?

Author(s): Yasir H. Siddique*

Volume 20 , Issue 6 , 2021

Published on: 20 April, 2021

Page: [480 - 486] Pages: 7

DOI: 10.2174/1871527320666210420140123

Price: $65

Abstract

Alpha-synuclein (α-synuclein) is a protein that is abundantly found in the brain and in a lesser amount in the heart and muscles. The exact role of α-synucleinis is not known, but it is considered to control the movement of synaptic vesicles. Its overexpression in the neurons leads to the formation of Lewy bodies that damage the dopaminergic neurons in the subtantianigra of the midbrain and leads to the progression of Parkinson’s Disease (PD). There are evidences showing that aggregates of α-synuclein behave like prions. The present review is an attempt to put forth the nature of α-synuclein as prions.

Keywords: α-synuclein, Parkinson's disease, prions, human, Lewy bodies, synaptic vesicles.

Graphical Abstract

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