摘要
大量证据证明,胆固醇代谢紊乱在糖尿病肾病中起着至关重要的作用。 此外,在糖尿病肾病患者和动物模型的内源性肾细胞中发现大量胆固醇沉积,引起细胞毒性并影响肾功能。 他汀类药物可以减轻糖尿病肾病的胆固醇沉积、足细胞损伤和微量白蛋白尿。 在这篇综述中,我们总结了胆固醇代谢紊乱的过程,并讨论了它如何在糖尿病肾病中引起肾功能障碍。
关键词: 胆固醇、糖尿病肾病、SREBP2、LDLR、ABCA1、ABCG1
Current Medicinal Chemistry
Title:The Role of Cholesterol Homeostasis in Diabetic Kidney Disease
Volume: 28 Issue: 36
关键词: 胆固醇、糖尿病肾病、SREBP2、LDLR、ABCA1、ABCG1
摘要: Considerable evidence has proved that disturbed cholesterol metabolism played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions were found in intrinsic renal cells of diabetic kidney disease patients and animal models, causing cytotoxicity and affecting renal function. Statins could alleviate cholesterol depositions, podocyte injury, and microalbuminuria of diabetic kidney disease. In this review, we summarized the process of disturbed cholesterol metabolism and discussed how it induced kidney dysfunction in diabetic kidney disease.
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The Role of Cholesterol Homeostasis in Diabetic Kidney Disease, Current Medicinal Chemistry 2021; 28 (36) . https://dx.doi.org/10.2174/0929867328666210419132807
DOI https://dx.doi.org/10.2174/0929867328666210419132807 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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