The Role of Cholesterol Homeostasis in Diabetic Kidney Disease

Xinyun       Chen; Qinghua       Yin; Liang       Ma; Ping       Fu

Abstract

Considerable evidence has proved that disturbed cholesterol metabolism played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions were found in intrinsic renal cells of diabetic kidney disease patients and animal models, causing cytotoxicity and affecting renal function. Statins could alleviate cholesterol depositions, podocyte injury, and microalbuminuria of diabetic kidney disease. In this review, we summarized the process of disturbed cholesterol metabolism and discussed how it induced kidney dysfunction in diabetic kidney disease.

Keywords: Cholesterol, diabetic kidney disease, SREBP2, LDLR, ABCA1, ABCG1.

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Current Medicinal Chemistry

Title:The Role of Cholesterol Homeostasis in Diabetic Kidney Disease

Volume: 28 Issue: 36

Author(s): Xinyun Chen, Qinghua Yin, Liang Ma* Ping Fu

Affiliation:

Kidney Research Institute, Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041,China

Keywords: Cholesterol, diabetic kidney disease, SREBP2, LDLR, ABCA1, ABCG1.

Abstract: Considerable evidence has proved that disturbed cholesterol metabolism played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions were found in intrinsic renal cells of diabetic kidney disease patients and animal models, causing cytotoxicity and affecting renal function. Statins could alleviate cholesterol depositions, podocyte injury, and microalbuminuria of diabetic kidney disease. In this review, we summarized the process of disturbed cholesterol metabolism and discussed how it induced kidney dysfunction in diabetic kidney disease.

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Cite this article as:

Chen Xinyun , Yin Qinghua , Ma Liang *, Fu Ping , The Role of Cholesterol Homeostasis in Diabetic Kidney Disease, Current Medicinal Chemistry 2021; 28(36) . https://dx.doi.org/10.2174/0929867328666210419132807

DOI https://dx.doi.org/10.2174/0929867328666210419132807	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X