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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Regulation of Protein Synthesis: An Approach to Treat Autism Spectrum Disorder (ASD)

Author(s): Jéssika Poliana Teixeira and Teodorico Castro Ramalho *

Volume 28 , Issue 34 , 2021

Published on: 19 April, 2021

Page: [7141 - 7156] Pages: 16

DOI: 10.2174/0929867328666210419125634

Price: $65

Abstract

Autism Spectrum Disorder (ASD) is a disorder with different etiologies and poor elucidation, characterized by changes in social and cognitive skills. ASD impacts a large number of people in the world. Surprisingly, in spite of its great importance, just modest progress has been achieved towards comprehending this pathology and designing new therapies. The molecular dysfunctions observed in people with autism are evidenced by the interference in the synthesis of synaptic proteins, which impairs their development and plasticity, leading to characteristics of individuals with ASD. The present work investigates the mTOR pathway and the proteins related to its regulation and neurological functioning. The path of protein synthesis and translation is promising to treat various disorders and its elucidation may, for example, result in drugs that facilitate the diagnosis and broaden the range of treatments, improving the quality of life of ASD patients.

Keywords: Neurodevelopment, translation, mTOR, eIF4E-eIF4G, mGluR, GRK5.


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