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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Regulating Inflammation Associated Ferroptosis - A Treatment Strategy for Parkinson Disease

Author(s): Marthandam Asokan Shibu, Mahalakshmi Bharath and Bharath Kumar Velmurugan*

Volume 28 , Issue 33 , 2021

Published on: 19 April, 2021

Page: [6895 - 6914] Pages: 20

DOI: 10.2174/0929867328666210419125032

Price: $65

Abstract

Ferroptosis plays a critical regulatory role as a new kind of cell death, initiating and developing an array of disorders like neurological diseases, acute injury of kidney, tumors, and ischemia, etc. Although selective deposition of iron is one of the pathogenic reasons for PD, it’s underlying mechanism is still unknown. In this review, the role of neuroinflammation in Parkinson’s disease (PD) leading to neurodegeneration has been discussed in detail. The accumulation of brain iron has been found in many chronic neurological disorders, including PD. We have also discussed the unique features of ferroptosis , and it links in aggravating the pathology of PD. Further, the concept of targeting ferroptosis for PD pathology and inducers and inhibitors, pharmacological drugs and clinical trials for PD candidates in phase IV stage in completed status are detailed in the respective sections.

Keywords: Ferroptosis, Parkinson's disease, iron accumulation, inflammation, neurodegeneration, drugs.


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