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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Review Article (Mini-Review)

Modulation of Huntington’s Disease in Drosophila

Author(s): Iqra Subhan and Yasir Hasan Siddique*

Volume 20 , Issue 10 , 2021

Published on: 12 April, 2021

Page: [894 - 903] Pages: 10

DOI: 10.2174/1871527320666210412155508

Price: $65

Abstract

Huntington’s disease (HD) is a progressive neurodegenerative disorder which deteriorates the physical and mental abilities of the patients. It is an autosomal dominant disorder and is mainly caused by the expansion of a repeating CAG triplet. A number of animal models ranging from worms, fruit flies, mice and rat, pig, sheep and monkeys are available, which have been helpful in understanding various pathways involved during the progression of the disease. Drosophila is one of the most commonly used model organisms for biomedical science, due to low cost maintenance, short life span and easy implications of genetic tools. The present review provides a brief description of HD and the studies carried out for HD to date, taking Drosophila as a model.

Keywords: Huntington's disease, drosophila, modulation, animal model, brain, trinucleotide repeats.

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