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Current Catalysis

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ISSN (Print): 2211-5447
ISSN (Online): 2211-5455

Research Article

Synthesis of Tri- and Tetra- Phenyl Substituted 1H-imidazoles in the Presence of Chitin and Pectin as Natural Catalyst

Author(s): Ghasem Marandi*, Salmeh Rasoulizadeh and Malek Taher Maghsoodlou

Volume 10 , Issue 2 , 2021

Published on: 04 April, 2021

Page: [154 - 161] Pages: 8

DOI: 10.2174/2211544710666210405094331

Price: $65

Abstract

Introduction: Chitin and pectin are important natural polymers which are used as a natural catalyst for the synthesis of tri- and tetra- phenyl substituted 1H-imidazoles.

Materials and Methods: The reaction of benzil and aromatic aldehydes with ammonium acetate in the presence of chitin produces 2,4,5-triphenyl-1H-imidazoles and the reaction of benzil, aromatic aldehydes and aniline derivatives with ammonium acetate in the presence of pectin produces 1,2,4,5- tetraphenyl-1H-imidazoles, respectively.

Results: The results show that the synthesis of 2,4,5-triphenyl-1H-imidazoles and 1,2,4,5-tetraphenyl- 1H-imidazoles can be catalyzed by chitin and pectin in an effective route, respectively. All synthesized compounds are in good agreement with previously reported compounds.

Conclusion: In conclusion, an efficient methodology has been carried out to generate 2,4,5-triphenyl- 1H-imidazoles and 1,2,4,5-tetraphenyl-1H-imidazoles, by using non-toxic, cheap and in available catalysis (chitin and pectin).

Keywords: Chitin and pectin, benzil, aromatic aldehydes, aniline or amine, tri- and tetra- phenyl substituted 1H-imidazoles, ammonium acetate.

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