摘要
自从sirtuins 在无数病理过程中发挥调节作用以来,人们对它们产生了浓厚的研究兴趣。在过去的二十年中,许多研究工作致力于开发 Sirtuin 调节剂。尽管合成 Sirtuin 调节剂是重点,但天然调节剂仍然是该领域有待进一步探索的一个组成部分,因为它们被发现具有治疗各种疾病的潜力,包括癌症、神经退行性疾病和代谢紊乱。由于这组化合物的重要性,本综述就天然存在的沉默调节蛋白调节剂、相关分子机制及其治疗益处给出了当前的立场。此外,通过全面的数据挖掘,对 2010-2020 年 Sirtuin 调节剂的发展趋势进行了详细的统计数据分析。最后,还将讨论天然sirtuin 调节剂在药物发现中的挑战和未来前景。
关键词: Sirtuins、天然产物、调节剂、药物发现、抑制剂、激活剂。
Current Medicinal Chemistry
Title:Natural Sirtuin Modulators in Drug Discovery: A Review (2010 -2020)
Volume: 28 Issue: 37
关键词: Sirtuins、天然产物、调节剂、药物发现、抑制剂、激活剂。
摘要: There have been intense research interests in sirtuins since the establishment of their regulatory roles in a myriad of pathological processes. In the last two decades, many research efforts have been dedicated to the development of sirtuin modulators. Although synthetic sirtuin modulators are the focus, natural modulators remain an integral part to be further explored in this area as they are found to possess therapeutic potential in various diseases, including cancers, neurodegenerative diseases, and metabolic disorders. Owing to the importance of this cluster of compounds, this review gives a current stand on the naturally occurring sirtuin modulators, associated molecular mechanisms, and their therapeutic benefits. Furthermore, comprehensive data mining resulted in detailed statistical data analysis pertaining to the developmental trend of sirtuin modulators from 2010-2020. Lastly, the challenges and future prospects of natural sirtuin modulators in drug discovery will also be discussed.
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Cite this article as:
Natural Sirtuin Modulators in Drug Discovery: A Review (2010 -2020), Current Medicinal Chemistry 2021; 28 (37) . https://dx.doi.org/10.2174/0929867328666210329124415
DOI https://dx.doi.org/10.2174/0929867328666210329124415 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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