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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Synaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle Docking, Priming, and Fusion

Author(s): Najeeb Ullah*, Ezzouhra El Maaiden, Md. Sahab Uddin* and Ghulam Md. Ashraf

Volume 22 , Issue 6 , 2021

Published on: 25 March, 2021

Page: [470 - 478] Pages: 9

DOI: 10.2174/1389203722666210325110231

Price: $65

Abstract

The fusion of secretory vesicles with the plasma membrane depends on the assembly of v-SNAREs (VAMP2/synaptobrevin2) and t-SNAREs (SNAP25/syntaxin1) into the SNARE complex. Vesicles go through several upstream steps, referred to as docking and priming, to gain fusion competence. The vesicular protein synaptotagmin-1 (Syt-1) is the principal Ca2+ sensor for fusion in several central nervous system neurons and neuroendocrine cells and part of the docking complex for secretory granules. Syt-1 binds to the acceptor complex such as synaxin1, SNAP-25 on the plasma membrane to facilitate secretory vesicle docking, and upon Ca2+-influx, it promotes vesicle fusion. This review assesses the role of the Syt-1 protein involved in the secretory vesicle docking, priming, and fusion.

Keywords: Synaptotagmin-1, vesicle docking, priming, fusion, exocytosis, secretory vesicles.

Graphical Abstract

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