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The International Journal of Gastroenterology and Hepatology Diseases


ISSN (Print): 2666-2906
ISSN (Online): 2666-2914


DILI Cases in Registries and Databases: An Analysis of Quality

Author(s): Rolf Teschke* and Gaby Danan

Volume 1 , Issue 1 , 2022

Published on: 25 March, 2021

Article ID: e010621192456 Pages: 4

DOI: 10.2174/2666290601666210325091553


Data quality of idiosyncratic drug-induced liver injury (iDILI) cases is insufficient in the US LiverTox database due to the lack of a robust causality assessment method such as the Roussel Uclaf Causality Assessment Method (RUCAM), not allowing for appropriate use of included cases by physicians. Despite some shortcomings, case quality is much better in national DILI registries using the prospective RUCAM, with a few exemptions.

Keywords: CAMs, causality assessment methods, DILI, drug-induced liver injury, HILI, herb induced liver injury, Roussel Uclaf Causality Assessment Method, RUCAM, DILI registries, LiverTox.

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