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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Tumor-Associated Macrophages as Potential Targets for Anti-Cancer Activity of Marine Invertebrate-Derived Compounds

Author(s): Lyudmila S. Dolmatova* and Igor Y. Dolmatov

Volume 27 , Issue 28 , 2021

Published on: 19 March, 2021

Page: [3139 - 3160] Pages: 22

DOI: 10.2174/1381612827666210319125652

Price: $65

Abstract

Tumor-associated macrophages (TAMs) are M2 phenotype dominant and promote tumor growth and metastasis. The new cancer treatment strategy includes TAM targeting and is aimed primarily at reprogramming TAMs toward the M1 phenotype or reducing the number and activity of M2 macrophages. Several marine invertebrate-derived drugs, combining efficacy and a low level of side effects, were approved for use in the cancer therapy. The mechanisms of action of some of them include TAM targeting. The review includes data showing immunomodulatory properties of these already approved anticancer drugs and drug candidates in clinical development which additionally incorporate data from screening studies of new substances from marine invertebrates. Based on screening data, the most promising marine compounds for cancer immunotherapy are supposed.

Keywords: Marine invertebrate-derived compounds, tumor-associated macrophages, macrophage reprogramming, cytokines, NO, anticancer drugs, cancer immunotherapy.


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