In recent years, the development of the chemical industry has been moving in a green, safe and efficient direction. Oxidation reactions are one of the most important types of reactions and have key applications in food, medicine, cosmetics, and petrochemicals. However, the occurrence of the oxidation reaction is accompanied by a strong exothermic phenomenon, and improper control can easily lead to safety problems and even explosions. The realization of an environmentally friendly oxidation reaction is a key industrial milestone. The unique structural characteristics of microreactors result in good mass and heat transfer performance, precise control of the reaction temperature, reduced risk of explosion, improved safety production and selectivity of products. These unique advantages of the microreactor determine its significant application value in oxidation reactions. In this paper, the research progress of several typical oxidation reactions, including alkane oxidation, alcohol oxidation, aldosterone oxidation, aromatics oxidation and olefin oxidation combined with microreactors, is reviewed systematically.