Abstract
Recent reports of the relationship between nickel, allergy and autoimmunity have been described. However, there remains a lack of information on the concordance between nickel sensitization and potency. Of note, an article by Drenovska et al. recommended a call for increased epidemiologic studies to define the prevalence of autoimmune syndromes induced by adjuvants such as nickel-containing metal implants. Accumulating reports of dermatologic manifestations following medical device implantation highlights the need for consideration regarding the potential sequelae following metal implantation. Considering the medical and the functional necessity of certain device materials, the authors agree calling for further epidemiological studies are needed to prevent metal-related autoimmunity, and additionally discover novel testing strategies.
Keywords: Immunology, allergy, nickel, autoimmune, epidemiology, metal implant, hypersensitivity
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Immunogenicity of Nickel-Further Explored
Volume: 21 Issue: 12
Author(s): Mohsen Baghchechi and Sharon E. Jacob
Affiliation:
Keywords: Immunology, allergy, nickel, autoimmune, epidemiology, metal implant, hypersensitivity
Abstract: Recent reports of the relationship between nickel, allergy and autoimmunity have been described. However, there remains a lack of information on the concordance between nickel sensitization and potency. Of note, an article by Drenovska et al. recommended a call for increased epidemiologic studies to define the prevalence of autoimmune syndromes induced by adjuvants such as nickel-containing metal implants. Accumulating reports of dermatologic manifestations following medical device implantation highlights the need for consideration regarding the potential sequelae following metal implantation. Considering the medical and the functional necessity of certain device materials, the authors agree calling for further epidemiological studies are needed to prevent metal-related autoimmunity, and additionally discover novel testing strategies.
Export Options
About this article
Cite this article as:
Baghchechi Mohsen and Jacob E. Sharon , Immunogenicity of Nickel-Further Explored, Endocrine, Metabolic & Immune Disorders - Drug Targets 2021; 21 (12) . https://dx.doi.org/10.2174/1871530321666210310143600
DOI https://dx.doi.org/10.2174/1871530321666210310143600 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Non-Analgesic Effects of Opioids: Opioid-induced Respiratory Depression
Current Pharmaceutical Design Prostacyclin, Atherothrombosis and Diabetes Mellitus: Physiologic and Clinical Considerations
Current Molecular Medicine Bibliometrics and Visualization of the Mechanisms of Parkinson's Diseases Based on Animal Models
Endocrine, Metabolic & Immune Disorders - Drug Targets Immune Restoration Disease: A Consequence of Dysregulated Immune Responses After HAART
Current HIV Research Unfoldomics of Human Genetic Diseases: Illustrative Examples of Ordered and Intrinsically Disordered Members of the Human Diseasome
Protein & Peptide Letters Chronic Tobacco Exposure by Smoking Develops Insulin Resistance
Endocrine, Metabolic & Immune Disorders - Drug Targets Cerebral Malaria - A Neurovascular Pathology with Many Riddles Still to be Solved
Current Neurovascular Research Metabolism of the Endocannabinoids Anandamide and 2-Arachidonoyl Glycerol, A Review, with Emphasis on the Pharmacology of Fatty Acid Amide Hydrolase, A Possible Target for the Treatment of Neurodegenerative Diseases and Pain
Current Medicinal Chemistry - Central Nervous System Agents A New Drug Candidate (GEMSP) for Multiple Sclerosis
Current Medicinal Chemistry Impact of Interleukin 28B and ICAM-1 Genetic Polymorphisms on Response to Direct Antiviral Treatment Among HCV Infected Patients
Endocrine, Metabolic & Immune Disorders - Drug Targets Anti-Inflammatory Effect of Ginsenoside Rg1 on LPS-Induced Septic Encephalopathy and Associated Mechanism
Current Neurovascular Research Synthesis, Antiproliferative, and Antioxidant Activities of Substituted N-[(1,3,4-Oxadiazol-2-yl) Methyl] Benzamines
Letters in Drug Design & Discovery A Chemo-Enzymatic Approach to Some Indole and Quinolizidine Alkaloids From Cs -Symmetric Precursors
Current Organic Chemistry Rediscovery of Caffeine: An Excellent Drug for Improving Patient Outcomes while Fighting WARS
Current Medicinal Chemistry Strategies for Non-Invasive Molecular Imaging of Acute Allograft Rejection by Gamma Scintigraphy and Positron Emission Tomography
Current Radiopharmaceuticals Mechanisms of Adipocytokine-Mediated Trastuzumab Resistance in HER2-Positive Breast Cancer Cell Lines
Current Pharmacogenomics and Personalized Medicine Genetic Surgery - A Right Strategy to Attack Cancer
Current Gene Therapy <sup>89</sup>Zr-PET Radiochemistry in the Development and Application of Therapeutic Monoclonal Antibodies and Other Biologicals
Current Topics in Medicinal Chemistry Potential Effect of Angiotensin II Receptor Blockade in Adipose Tissue and Bone
Current Pharmaceutical Design AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes?
Current Drug Targets