Quantitative Structure Activity Relationship Studies of Antimicrobial Compounds: A Review

Sahaya       Asirvatham; Jyoti       Thakur; Savita       Tauro; Bharat       Dhokchawle

Abstract

With the current scenario of emerging drug-resistant microbial strains, there prevails a continuous threat to health and the development of new antimicrobial agents is a challenging task. Quantitative Structure Activity Relationship (QSAR) has proven to elevate the likelihood of finding a new pharmacophore. Intermolecular binding like hydrophobic bond, electrostatic and steric interactions helps to understand drug interaction with the receptors. Some common conclusions have been drawn after analyzing diverse case studies. Few descriptors were identified to be common in enhancing the antimicrobial activity. The structural features modifying the antimicrobial activity were analyzed using critically published results from significant QSAR studies on antimicrobial compounds. This commentary will assist the synthetic chemist in synthesizing novel derivatives, which could be potential antimicrobial compounds.

Keywords: Quantitative structure activity relationships, antimicrobial, drug-resistance, descriptors.

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Anti-Infective Agents

Title:Quantitative Structure Activity Relationship Studies of Antimicrobial Compounds: A Review

Volume: 19 Issue: 4

Author(s): Sahaya Asirvatham*, Jyoti Thakur, Savita Tauro and Bharat Dhokchawle

Affiliation:

Department of Pharmaceutical Chemistry, St. John Institute of Pharmacy and Research, Palghar-401404,India

Keywords: Quantitative structure activity relationships, antimicrobial, drug-resistance, descriptors.

Abstract: With the current scenario of emerging drug-resistant microbial strains, there prevails a continuous threat to health and the development of new antimicrobial agents is a challenging task. Quantitative Structure Activity Relationship (QSAR) has proven to elevate the likelihood of finding a new pharmacophore. Intermolecular binding like hydrophobic bond, electrostatic and steric interactions helps to understand drug interaction with the receptors. Some common conclusions have been drawn after analyzing diverse case studies. Few descriptors were identified to be common in enhancing the antimicrobial activity. The structural features modifying the antimicrobial activity were analyzed using critically published results from significant QSAR studies on antimicrobial compounds. This commentary will assist the synthetic chemist in synthesizing novel derivatives, which could be potential antimicrobial compounds.

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Cite this article as:

Asirvatham Sahaya *, Thakur Jyoti , Tauro Savita and Dhokchawle Bharat , Quantitative Structure Activity Relationship Studies of Antimicrobial Compounds: A Review, Anti-Infective Agents 2021; 19 (4) : e130621192101 . https://dx.doi.org/10.2174/2211352519666210308102017

DOI https://dx.doi.org/10.2174/2211352519666210308102017	Print ISSN 2211-3525
Publisher Name Bentham Science Publisher	Online ISSN 2211-3533

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