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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article (Mini-Review)

Glitazones, PPAR-γ and Neuroprotection

Author(s): Ashwini Prem Kumar, Prabitha P, B.R. Prashantha Kumar, Victoria Jeyarani, S.P. Dhanabal and Antony Justin*

Volume 21 , Issue 12 , 2021

Published on: 04 March, 2021

Page: [1457 - 1464] Pages: 8

DOI: 10.2174/1389557521666210304112403

Price: $65

Abstract

The transcriptional factor PPAR-γ belongs to the nuclear receptor family, which has become a potential therapeutic target for several neurodegenerative diseases and metabolic disorders. Interestingly, PPAR-γ has been reported to have beneficial effects in various chronic neurological conditions via upregulation of its transcriptional co-activator PGC-1α and followed by regulation of multiple molecular events. Although several factors contribute to the progression of neurodegeneration, the dysfunction of PGC-1α expression is primarily interlinked with the pathogenesis of major neurodegenerative diseases. This review gives an insight that ligand-dependent activation of PPAR-γ by glitazones could initiate the structural conformational changes of the secondary proteins, thus recruiting the PGC-1α to form a stable regulatory complex that hampers the various molecular pathways contributing to neurodegeneration. The promising outcomes of the preliminary in silico studies included in this review support that PPAR-γ dependent activation of central PGC-1α signaling by novel glitazones is an encouraging strategy to enhance the oxy-radicals detoxifying system, antiinflammatory responses, and mitochondrial biogenesis required for neuroprotection in various neurodegenerative conditions.

Keywords: PPAR-γ, glitazones, conformational changes, cytokines, mitochondrial biogenesis, neuroprotection.

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