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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Therapeutic Potential of microRNA Against Th2-associated Immune Disorders

Author(s): Sunil Kumar, Muhammad Umer Ashraf, Anil Kumar and Yong-Soo Bae*

Volume 21 , Issue 8 , 2021

Published on: 03 March, 2021

Page: [753 - 766] Pages: 14

DOI: 10.2174/1568026621666210303150235

Price: $65

Abstract

MicroRNAs (miRNAs) are short ~18-22 nucleotide, single-stranded, non-coding RNA molecules playing a crucial role in regulating diverse biological processes and are frequently dysregulated during disease pathogenesis. Thus, targeting miRNA could be a potential candidate for therapeutic invention. This systemic review aims to summarize our current understanding regarding the role of miRNAs associated with Th2-mediated immune disorders and strategies for therapeutic drug development and current clinical trials.

Keywords: microRNA therapeutics, Th2-disorder, Dendritic cells, Asthma, Atopic dermatitis, Rhinitis.

Graphical Abstract

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