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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Anti-breast Cancer Potential of Natural and Synthetic Coumarin Derivatives

Author(s): Feng Song, Xiankai Huo and Zeying Guo*

Volume 21 , Issue 18 , 2021

Published on: 03 March, 2021

Page: [1692 - 1709] Pages: 18

DOI: 10.2174/1568026621666210303145430

Price: $65


Breast cancer is the most frequent female cancer and one of the leading causes of cancer death in women. There are many chemotherapy agents available for the treatment of breast cancer. Still, the current therapeutic options have not fulfilled the desired outcomes, especially for drug-resistant breast cancer therapy. Thus, there is an urgent need to develop novel anti-breast cancer agents. Coumarin is ubiquitous in natural and synthetic bioactive compounds, and coumarin derivatives readily interact with a variety of enzymes and receptors in breast cancer cells. Moreover, the coumarin-based irosustat as the first-generation steroid sulfatase inhibitor in breast cancer is under clinical evaluation, revealing the potential of coumarin derivatives as novel anti-breast cancer agents. This review aims to describe the recent development of natural and synthetic coumarin derivatives with anti-breast cancer potential, covering the articles published from 2015 to 2020.

Keywords: Coumarin, Natural product, Dimers, Hybrids, Breast cancer, Steroid, Cancer cells.

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