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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Apo A-1 Mimetic Peptides as Atheroprotective Agents in Murine Models

Author(s): Mohamad Navab, G. M. Anantharamaiah, Srinivasa T. Reddy, Brian J. Van Lenten and Alan M. Fogelman

Volume 9, Issue 3, 2008

Page: [204 - 209] Pages: 6

DOI: 10.2174/138945008783755584

Price: $65

Abstract

The mouse has proven to be an excellent model for testing apolipoprotein mimetic peptides as agents to treat a variety of vascular inflammatory conditions including atherosclerosis, cognitive dysfunction associated with arteriole inflammation, chronic rejection of transplanted hearts, and scleroderma. The mechanism of action appears to relate to the ability of these peptides to preferentially bind pro-inflammatory oxidized lipids and is independent of the chirality of the peptides since peptides synthesized from either D- or L-amino acids appear to be equally effective.


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