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Current Cancer Therapy Reviews


ISSN (Print): 1573-3947
ISSN (Online): 1875-6301

Research Article

Effect of Conventional Chemotherapies on Natural Killer Cell Activity

Author(s): Idris Kirhan*, Huseyin Taskiran and Ataman Gönel

Volume 17, Issue 3, 2021

Published on: 22 February, 2021

Page: [251 - 254] Pages: 4

DOI: 10.2174/1573394717666210223111332

Price: $65


Background: The effects of chemotherapeutics agents are considered to influence the immune system and cells due to their myelosuppressive and immunosuppressive functions. Natural killer cells are one of the important components of the innate immune system and have a critical role against tumor cells and infections.

Objective: The study was aimed to demonstrate whether conventional chemotherapies had an effect on Natural Killer (NK) cell activity.

Methods: Forty-nine adjuvant and 19 first-time metastatic chemotherapy-naïve cancer patients were recruited into the study. Blood samples at pre-chemotherapy and post-chemotherapy, at 1st and 4th cycles, were obtained for NK cell activity.

Results: We found no difference between baseline and post-chemotherapy NK cell activity levels. In addition, we found no difference between pre-chemotherapy and post-chemotherapy NK cell activity in both adjuvant and metastatic cancer patients separately.

Conclusion: Conventional chemotherapy seems to have no effect on NK cell activity levels in cancer patients in both metastatic and adjuvant settings.

Keywords: NK cell activity, cancer, pre-chemotherapy, post-chemotherapy, adjuvant, metastasis.

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