Overview of the Biological Activities of Pyrimido[4,5-d]pyrimidines

Title:Overview of the Biological Activities of Pyrimido[4,5-d]pyrimidines

Volume: 21 Issue: 15

Author(s): Jacqueline Santos Cruz *Alcino Palermo de Aguiar

Affiliation:

• Department of Chemistry, Military Institute of Engineering, Rio de Janeiro,Brazil

Keywords: Pyrimidopyrimidine, fused pyrimidines, pyrimidines, heterocycles, antimicrobial, diuretic, antifolate.

Abstract: Over the years, the development of bioactive heterocycles has aroused the interest of the scientific community, because in general, these heterocycles are strategic in maintaining life. Research into bioactive heterocycles is associated with the development of methods of synthesis and the biological evaluation of different nuclei. In consequence, there has been a growing interest in the nucleus of fused pyrimidine, which has diversified pharmacological activities, including diuretic, antimicrobial, antifolate, tyrosine kinase, anti-inflammatory, anticancer, anthelminthic, and antiviral activities. This review focuses on describing a diverse set of structures derived from pyrimido[4,5-d]pyrimidines and contemplates the main bioactivities of these nuclei.

Cite this article as:

Cruz Santos Jacqueline *, de Aguiar Palermo Alcino , Overview of the Biological Activities of Pyrimido[4,5-d]pyrimidines, Mini-Reviews in Medicinal Chemistry 2021; 21 (15) . https://dx.doi.org/10.2174/1389557521666210219160115