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Current Rheumatology Reviews


ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Research Article

The Paradoxical Reaction to Rituximab in Six Granulomatosis with Polyangiitis Patients: How Could it be Explained and Managed?

Author(s): Samira Alesaeidi, Seyed Mohammad Piri and Soheil Tavakolpour*

Volume 17 , Issue 3 , 2021

Published on: 19 February, 2021

Page: [327 - 330] Pages: 4

DOI: 10.2174/1573397117666210219121659

Price: $65


Background: Granulomatosis with polyangiitis is a systemic anti-neutrophil cytoplasmic antibody-associated vasculitides (AAVs), mainly involving the respiratory tract and renal system. Treatment by Rituximab as a next-generation therapy in ANCA-associated vasculitis is associated with promising outcomes in GPA patients. Despite symptoms improvements, disease recurrence and drug reaction are a challenging topic nowadays.

Objectives: In this study, we examined six GPA patients who were confirmed to have paradoxical reactions to rituximab and then described how to control their symptoms.

Methods: In this study, all the systemic GPA patients (diagnosed based on ACR/EULAR criteria) who received RTX in Amir-Allam hospital were monitored for any sign of disease exacerbation up to 3 months after RTX exposure.

Results: From 78 GPA-diagnosed patients, six, including one man and five women with the mean age of 37.3 ± 13.8, were identified for exacerbation after RTX administration.

Conclusion: According to our observation, it could be recommended not to deprive the patient of the benefits of RTX treatment due to the early patient's possible complications.

Keywords: Granulomatosis with polyangiitis, Wegener's Granulomatosis, rituximab, ANCA, RTX, paradoxical.

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