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Current Alzheimer Research


ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Research Article

Relationship of Neurofilament Light (NfL) and Cognitive Performance in a Sample of Mexican Americans with Normal Cognition, Mild Cognitive Impairment and Dementia

Author(s): James R. Hall*, Leigh A. Johnson, Melissa Peterson, David Julovich, Tori Como and Sid E. O’Bryant

Volume 17, Issue 13, 2020

Page: [1214 - 1220] Pages: 7

DOI: 10.2174/1567205018666210219105949

Price: $65


Introduction: This study characterized the relationship between plasma NfL and cognition in a community-based sample of older Mexican Americans.

Methods: 544 participants completed a battery of neuropsychological tests and were diagnosed using clinical criteria. NfL was assayed using Simoa. NfL levels across groups and tests were analyzed.

Results: Difference in NfL was found between normal and impaired groups and was related to global cognition, processing speed, executive functions and a list of learning tasks with a significant negative effect for all diagnostic groups. NfL had a negative impact on processing speed, attention, executive functions and delayed and recognition memory for both normal and MCI groups.

Conclusion: The research supports plasma NfL as a marker of cognitive impairment related to neurodegenerative processes in Mexican Americans and may be a marker of early changes in cognition in those with normal cognition and at risk for developing MCI.

Keywords: Neurofilament light, mexican americans, cognition processes, normal cognition, MCI, dementia.

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