Background: Antiretroviral therapy (ART) has led to a decline in autoimmune diseases but lacks studies on its effect on autoantibodies.Methods: It is a cross-sectional study with archived samples from 100 paired HIV-1 infected ART naïve and experienced individuals and 100 prospectively collected matched blood-donor controls. Antinuclear antibody, IgG anticardiolipin antibody, IgM and IgG β2 glycoprotein-1 antibodies, and total IgG levels were detected. Results are expressed as mean with standard deviation (SD), median, percentage positivity, and a p<0.05 is considered significant. The study was approved by the Institutional Review Board. Results: The median viral load of the treatment naïve samples was 4.34 Log copies/mL, while all were virally suppressed post ART with a median duration of treatment for 12 months (range: 3-36 months). The percentage of antinuclear antibody positivity was 5% among ART naïve and controls, with a decrease of 2% post ART (p= 0.441). The positivity for anti-cardiolipin antibody was 15% among ART naïve while none of the ART experienced or controls were positive (p<0.05). IgM β2 glycoprotein-1 were 4%, 1% and 3% among ART naïve, treated and controls, respectively (p<0.05). IgG β2 glycoprotein-1 was 2% among ART naïve while none of the treated and controls were positive (p<0.05). The mean total IgG level among ART naïve, experienced, and controls were 21.82 (SD 6.67), 16.91 (SD 3.38), 13.70 (SD 2.24) grams/Litre, respectively (p<0.05). Conclusion: ART has a significant effect on IgG anti-cardiolipin antibody and total IgG but only a marginal effect on ANA, IgM, and IgG β2 glycoprotein-1 antibodies.
Keywords: Autoantibodies, anti-nuclear antibody (ANA), IgG anti-cardiolipin antibody (aCL), IgM and IgG anti-beta 2 glycoprotein- 1 antibodies (β2 GP1), autoimmunity, HIV-1 infection, antiretroviral therapy, ART naïve and ART experienced.
[http://dx.doi.org/10.1111/j.1365-2249.2008.03834.x] [PMID: 19076824]
[http://dx.doi.org/10.3390/v11080762] [PMID: 31430946]
[http://dx.doi.org/10.1046/j.1365-4362.2002.01529.x] [PMID: 12121558]
[http://dx.doi.org/10.1128/CDLI.5.2.181-185.1998] [PMID: 9521140]
[http://dx.doi.org/10.1097/00002030-199715000-00009] [PMID: 9412703]
[http://dx.doi.org/10.1097/00002030-199209000-00004] [PMID: 1388904]
[http://dx.doi.org/10.1111/j.1365-2249.1992.tb06408.x] [PMID: 1733634]
[http://dx.doi.org/10.1371/journal.pone.0127662] [PMID: 26599070]
[http://dx.doi.org/10.1111/j.1365-2249.2004.02575.x] [PMID: 15373919]
[http://dx.doi.org/10.1046/j.1365-2249.2002.01713.x] [PMID: 11882039]
[http://dx.doi.org/10.1111/j.1365-2249.1990.tb03328.x] [PMID: 2387093]
[http://dx.doi.org/10.1006/jaut.1999.0324] [PMID: 10550222]
[http://dx.doi.org/10.2165/00003495-200868020-00004] [PMID: 18197725]