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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Review Article

Effects of Deep Brain Stimulation on Sleep-Wake Disturbances in Patients with Parkinson's Disease: A Narrative Review

Author(s): Yu Jin Jung, Han-Joon Kim*, Sun Ha Paek and Beomseok Jeon

Volume 19 , Issue 10 , 2021

Published on: 15 February, 2021

Page: [1716 - 1727] Pages: 12

DOI: 10.2174/1570159X19666210215115718

Price: $65


Sleep-wake disturbances (SWD) are one of the most common non-motor symptoms in the Parkinson's disease (PD) and can appear in the early stage, even before the onset of motor symptoms. Deep brain stimulation (DBS) is an established treatment for the motor symptoms in patients with advanced PD. However, the effect of DBS on SWD and its specific mechanisms are not widely understood and remain controversial. In addition to the circuit-mediated direct effect, DBS may improve SWD by an indirect effect, such as the resolution of nocturnal motor complications and a reduction of dopaminergic medication. Here, the authors review the recent literatures regarding the impact of DBS on SWD in patients with PD. Furthermore, the selection of the DBS targets and the specific effects of applying DBS to each target on SWD in PD are also discussed.

Keywords: Parkinson's disease, deep brain stimulation, sleep-wake disturbances, sleep quality, sleep architecture, excessive daytime sleepiness, REM sleep behavior disorder, restless leg syndrome.

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