An Efficient One-pot Stereoselective Synthesis of 2,6-disubstituted 4-thiocyanatotetrahydropyrans

Title:An Efficient One-pot Stereoselective Synthesis of 2,6-disubstituted 4-thiocyanatotetrahydropyrans

Volume: 8 Issue: 3

Author(s): Chithaluri Sudhakar*Pochamoni Ramudu

Affiliation:

• Department of Chemistry, GITAM School of Science, GITAM Deemed to be University, Telangana-502 329,India

Keywords: Aldehydes, allyl trimethylsilane, lewis acid, prins cyclization, thiocyanatotetrahydropyran, one-pot reaction.

Abstract: An efficient stereoselective synthesis of 2,6-disubstituted-4-thiocyanatotetrahydropyrans has been developed through a one-pot three-component reaction of aldehydes, trimethyl allylsilane, and NH₄SCN in the presence of BF₃.Et₂O at room temperature. The products are formed rapidly (10-30 min) in excellent yields (78-98%).

Cite this article as:

Sudhakar Chithaluri *, Ramudu Pochamoni , An Efficient One-pot Stereoselective Synthesis of 2,6-disubstituted 4-thiocyanatotetrahydropyrans, Current Organocatalysis 2021; 8 (3) . https://dx.doi.org/10.2174/2213337208666210212121506