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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Furanodiene: A Novel, Potent, and Multitarget Cancer-fighting Terpenoid

Author(s): Rabia Batool, Azhar Rasul*, Ghulam Hussain, Muhammad Ajmal Shah*, Bushra Nageen, Iqra Sarfraz, Muhammad Kashif Zahoor, Ammara Riaz, Aiza Ajaz and Şevki Adem

Volume 27 , Issue 22 , 2021

Published on: 11 February, 2021

Page: [2628 - 2634] Pages: 7

DOI: 10.2174/1381612827666210211125304

Price: $65

Abstract

Natural products have served as a limitless reservoir of bioactive scaffolds for drug discovery against several disorders. Furanodiene is a bioactive natural product isolated from several plants of genus Curcuma. Its therapeutic potential against cancer, inflammation, and angiogenesis has been well-documented. The current review is an update about the natural sources and anti-cancer action mechanism of furanodiene. Furanodiene exerts its anti-cancer effects via induction of apoptosis in several cancer types by modulating MAPKs/ERK, NF-κB, and Akt pathways. Furanodiene has been systematically studied for its anti-cancer potential. However, pharmacokinetics, pharmacodynamics, pre-clinical and clinical studies still needed to be conducted to completely validate the potential of furanodiene for the treatment of cancer.

Keywords: Furanodiene, natural compound, terpenoid, sesquiterpene, anti-cancer, antioxidant, Curcuma.


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