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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607


Glycyrrhizin as a Potential Treatment for the Novel Coronavirus (COVID-19)

Author(s): Habeb Al-Kamel* and Oliver Grundmann

Volume 21, Issue 16, 2021

Published on: 10 February, 2021

Page: [2204 - 2208] Pages: 5

DOI: 10.2174/1389557521666210210160237


COVID-19 is an emerging viral infection of zoonotic origin that is closely related to the severe acute respiratory syndrome coronavirus (SARS-CoV) that caused an outbreak in 2003. Therefore, scientists named the new virus SARS-CoV-2. On March 11, 2020, The World Health Organization (WHO) recognized COVID-19 as a global pandemic. At present, three vaccines have been approved or are being considered for approval by national regulatory agencies to immunize against COVID- 19. However, the vaccines do not remain widely available, and no specific treatment against the virus is available. The pathogenesis and proliferation pathways of SARS-CoV-2 are still not well known. Thus, in this article, the saponin glycyrrhizin is discussed as a new potential therapeutic agent of natural origin (licorice root, Glycyrrhiza glabra) for the potential treatment of COVID-19 infections.

Keywords: Coronavirus, SARS-COV-2, COVID-19, glycyrrhizin, broad-spectrum antiviral agent, licorice Root.

Graphical Abstract

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