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Current Molecular Pharmacology


ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

Review Article

Di'ao Xinxuekang: Therapeutic Potential in Cardiovascular Diseases

Author(s): Shengyu Zhang, Lingli Li, Mingying Deng, Yanan Wang, AiZong Shen and Lei Zhang*

Volume 14, Issue 6, 2021

Published on: 03 February, 2021

Article ID: e301221191119 Pages: 11

DOI: 10.2174/1874467214666210203212341

Price: $65


Background: Cardiovascular disease is the leading cause of death in both developed and developing countries. Di'ao Xinxuekang (DAXXK) is a pure Chinese medicine herbal preparation refined from dioscin extracted from the roots of Dioscorea panthaica Prain et Burk and Diosorea nipponica Makino.

Objective: To evaluate the application of DAXXK in Cardiovascular disease.

Methods: We searched and summarized all the studies on DAXXK and Cardiovascular disease in Pubmed, Google, and CNKI.

Results: Modern pharmacological studies have shown that DAXXK has pharmacological effects such as dilating blood vessels, lowering blood pressure and cardiac load, improving hemodynamics, lowering blood lipids and anti-platelet aggregation, and is widely used for the therapy of various kinds of cardiovascular diseases, including hypertension, atherosclerosis, coronary heart disease (CHD), angina pectoris (AP) and myocardial infarction. We provide an overview of the clinical efficacy, molecular mechanisms, safety and therapeutic potential of DAXXK in the treatment of cardiovascular disease, aiming to provide clues and evidence for clinical decision-making.

Conclusion: DAXXK exerts cardiovascular protection by regulating a variety of cardiovascular disease- related signaling pathways.

Keywords: Angina pectoris, hypertension, cardiovascular diseases, Di'ao Xinxuekang, coronary artery disease

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