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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Review Article

Recent Trend in the Chemistry of Triazolopyrimidines and their Applications

Author(s): Mounir A. Salem, Mohamed S. Behalo and Rizk E. Khidre*

Volume 18, Issue 8, 2021

Published on: 03 February, 2021

Page: [1134 - 1149] Pages: 16

DOI: 10.2174/1570193X18666210203155358

Price: $65


This review deals with the synthetic methods, chemical reactions, and applications of triazolopyrimidine derivatives. The synthetic methods and chemical reactions are subdivided into groups according to the junction between triazole and pyrimidine moieties for instance [1,2,4]triazolo[1,5- a]pyrimidine, [1,2,4]triazolo[1,5-c]pyrimidine, [1,2,3]triazolo[1,5-a]pyrimidine, [1,2,3]triazolo[1,5- c]pyrimidine, [1,2,4]triazolo[4,3-c]pyrimidine, and [1,2,4]triazolo[4,3-a]pyrimidine. Pharmacological activity of triazolopyrimidins is also reported.

Keywords: Triazolopyrimidine, pyrimidine, triazole, synthesis, heterocycles, pharmacological activities.

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