Abstract
In December 2019, a new severe acute respiratory coronavirus (SARS- COV-2) had caused outbreaks of pneumonia in Wuhan city, China. It was known as coronavirus infected disease-2019 (COVID-19). COVID-19 patients typically have a fever and respiratory syndrome, where the lung is the main target organ affected by this virus. The objective of this review is to monitor and evaluate injuries caused by the SARS-COV-2 virus on multiple organs other than the lung as the gastrointestinal tract, liver, kidney, heart, ovary, ocular, olfactory, gonad, skin, central nervous system, and sense organs. As SARS- COV-2 virus enters host cells via cell receptor angiotensin circulating enzyme-2 (ACE2), so it is important to identify the main target cells attacked by SARS- COV-2 virus by comparing the ACE2 expression and viral upload in different organs. In conclusion, the definite role of body organs is explored in the manifestation of COVID-19 infection and crosstalk between other organs are useful tools to find any correlation between disease severity and organs dysfunction, exact prognosis, disease prevention measures, clinical care, and treatment strategies.
Keywords: COVID-19, viral detection, organs crosstalk, organs dysfunction, prognosis, clinical care.
Coronaviruses
Title:COVID-19 Invades Several Important Organs other than the Lungs: Organs Crosstalk
Volume: 2 Issue: 10
Author(s): Manal A. Hamed*
Affiliation:
- Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza,Egypt
Keywords: COVID-19, viral detection, organs crosstalk, organs dysfunction, prognosis, clinical care.
Abstract: In December 2019, a new severe acute respiratory coronavirus (SARS- COV-2) had caused outbreaks of pneumonia in Wuhan city, China. It was known as coronavirus infected disease-2019 (COVID-19). COVID-19 patients typically have a fever and respiratory syndrome, where the lung is the main target organ affected by this virus. The objective of this review is to monitor and evaluate injuries caused by the SARS-COV-2 virus on multiple organs other than the lung as the gastrointestinal tract, liver, kidney, heart, ovary, ocular, olfactory, gonad, skin, central nervous system, and sense organs. As SARS- COV-2 virus enters host cells via cell receptor angiotensin circulating enzyme-2 (ACE2), so it is important to identify the main target cells attacked by SARS- COV-2 virus by comparing the ACE2 expression and viral upload in different organs. In conclusion, the definite role of body organs is explored in the manifestation of COVID-19 infection and crosstalk between other organs are useful tools to find any correlation between disease severity and organs dysfunction, exact prognosis, disease prevention measures, clinical care, and treatment strategies.
Export Options
About this article
Cite this article as:
Hamed A. Manal *, COVID-19 Invades Several Important Organs other than the Lungs: Organs Crosstalk, Coronaviruses 2021; 2 (10) : e170821191026 . https://dx.doi.org/10.2174/2666796702666210202124650
DOI https://dx.doi.org/10.2174/2666796702666210202124650 |
Print ISSN 2666-7967 |
Publisher Name Bentham Science Publisher |
Online ISSN 2666-7975 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases – Part I
Current Medicinal Chemistry Oxidative Stress During Myocardial Ischaemia and Heart Failure
Current Pharmaceutical Design The Role of Nitro (NO<sub>2</sub>-), Chloro (Cl), and Fluoro (F) Substitution in the Design of Antileishmanial and Antichagasic Compounds
Current Drug Targets Role of PI3K/AKT/mTOR Pathway Associated Oxidative Stress and Cardiac Dysfunction in Takotsubo Syndrome
Current Neurovascular Research Polymorphism Gln27Glu of β2 Adrenergic Receptors in Patients with Ischaemic Cardiomyopathy
Current Vascular Pharmacology Urinary Steroids Measured by Modern Separation Techniques and Applied as Biomarkers in Stress Studies
Current Pharmaceutical Analysis Protecting the Heart: Biological Targets and Clinical Strategies
Current Pharmaceutical Design Autonomic Nervous System in Viral Myocarditis: Pathophysiology and Therapy
Current Pharmaceutical Design The Role of Beta-Blocker in Heart Failure in Adults with Congenital Heart Disease
Reviews on Recent Clinical Trials Drug Therapy of Neuropathic Pain: Current Developments and Future Perspectives
Current Drug Targets Cell Based Approaches for Myocardial Regeneration and Artificial Myocardium
Current Stem Cell Research & Therapy Genetic Predisposition in NAFLD and NASH: Impact on Severity of Liver Disease and Response to Treatment
Current Pharmaceutical Design Preclinical Development of New Therapy for Glycogen Storage Diseases
Current Gene Therapy Histological Alterations in the Testicular Tissue Induced by Sildenafil Overdoses
Drug Metabolism Letters Transcription Factor CHF1/Hey2 Regulates Specific Pathways in Serum Stimulated Primary Cardiac Myocytes: Implications for Cardiac Hypertrophy
Current Genomics Therapeutic Angiogenesis in Ischemic Tissues by Growth Factors and Bone Marrow Mononuclear Cells Administration: Biological Foundation and Clinical Prospects
Current Stem Cell Research & Therapy Takotsubo-Like Left Ventricular Dysfunction in an HIV-Infected Patient
Current HIV Research Epsilon Waves as an Extreme Form of Depolarization Delay: Focusing on the Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
Current Cardiology Reviews Urocortins: Putative Role in Cardiovascular Disease
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Statins and Oxidative Stress in the Cardiovascular System
Current Pharmaceutical Design