Dynamics of Toll-like Receptors Signaling in Skeletal Muscle Atrophy

Title:Dynamics of Toll-like Receptors Signaling in Skeletal Muscle Atrophy

Volume: 28 Issue: 28

Author(s): Aarti Yadav, Anil Dahuja and Rajesh Dabur*

Affiliation:

• Clinical Research Laboratory, Department of Biochemistry, Maharshi Dayanand University, Rohtak-124001, Haryana,India

Keywords: Toll-like receptors, skeletal muscle atrophy, inflammation, oxidative stress, pro-inflammatory cytokines.

Abstract: Skeletal muscle atrophy has been characterized as a state of uncontrolled inflammation and oxidative stress that escalates protein catabolism. Recent advancement supports impinging signaling molecules in the muscle fibers controlled through toll-like receptors (TLR). Activated TLR signaling pathways have been identified as inhibitors of muscle mass and provoke the settings for muscle atrophy. Among them, mainly TLR2 and TLR4 manifest their presence to exacerbate the release of the pro-inflammatory cytokine to deform the synchronized muscle programming. The present review enlightens the TLR signaling mediated muscle loss and the interplay between inflammation and skeletal muscle growth.

Cite this article as:

Yadav Aarti , Dahuja Anil and Dabur Rajesh *, Dynamics of Toll-like Receptors Signaling in Skeletal Muscle Atrophy, Current Medicinal Chemistry 2021; 28(28) . https://dx.doi.org/10.2174/0929867328666210202113734