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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Dynamics of Toll-like Receptors Signaling in Skeletal Muscle Atrophy

Author(s): Aarti Yadav, Anil Dahuja and Rajesh Dabur*

Volume 28, Issue 28, 2021

Published on: 02 February, 2021

Page: [5831 - 5846] Pages: 16

DOI: 10.2174/0929867328666210202113734

Price: $65


Skeletal muscle atrophy has been characterized as a state of uncontrolled inflammation and oxidative stress that escalates protein catabolism. Recent advancement supports impinging signaling molecules in the muscle fibers controlled through toll-like receptors (TLR). Activated TLR signaling pathways have been identified as inhibitors of muscle mass and provoke the settings for muscle atrophy. Among them, mainly TLR2 and TLR4 manifest their presence to exacerbate the release of the pro-inflammatory cytokine to deform the synchronized muscle programming. The present review enlightens the TLR signaling mediated muscle loss and the interplay between inflammation and skeletal muscle growth.

Keywords: Toll-like receptors, skeletal muscle atrophy, inflammation, oxidative stress, pro-inflammatory cytokines.

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