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Current Bioactive Compounds


ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Review Article

Phytochemicals from Peanut (Arachis hypogaea L.) Skin Extract with Potential for Pharmacological Activity

Author(s): Sampson Kofi Kyei*, William Iheanyi Eke, Hajara Abdul-Karim, Godfred Darko and Onyewuchi Akaranta

Volume 17, Issue 9, 2021

Published on: 01 February, 2021

Article ID: e190721190997 Pages: 19

DOI: 10.2174/1573407217666210202092052

Price: $65


Background: Plant phenolics, commonly present in legumes, leafy vegetables, fruits, grains are a key source of bioactive nutrients existing as flavonols, flavanones, flavanols, phytosterols, among others. Peanuts, being crops of high commercial use, undergo processing that generates voluminous agro-wastes. The waste comprises both the shells and skins, which could be valorized. Its versatile functionality has encouraged extensive research into peanut skin-derived chemicals for diverse applications over the past few decades. Peanut skin, however, is ascertained to be rich in flavonoids, stilbenes (resveratrol), and other phenolic compounds.

Methods: This review presents the biologically active compounds and pharmacological activities of peanut skins and their related works over the past few years. Articles carefully chosen from broad databases such as Scopus, Science Direct, Pub Med, SciFinder, among others, were used as the primary data.

Results: The bioactive components of peanut skin extracts exhibit anti-oxidant, anti-inflammatory, anti-bacterial, anti-viral, anti-fungal, anti-cancer/anti-tumour, anti-cardiovascular, and anti-diabetes/ obesity activities via in vitro and in vivo models. Besides, their varied biological properties make them potential precursors for the management of diverse diseases and ailments. Potential Applications: Phytochemicals from peanut skins could be deployed as antioxidant, antidiabetic and antimicrobial agents in drugs for the clinical treatment of ailments with extensive clinical applications.

Conclusion: The present review covers the chemistry and pharmacological activities of peanut skin phytochemicals. Our findings in this review substantiate the importance of peanut skin extracts and their varied potential for the treatment of specific diseases. The results indicate that they are attractive target compounds for the development of new drugs. We hope that this information will inform further in vivo studies on the role of peanut skin phenolic compounds in our health.

Keywords: Agro-wastes, peanut skin, phenolic compounds, bioactive components, pharmacological activity, in vivo.

Graphical Abstract
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