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Current Drug Research Reviews


ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

Letter Article

Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer

Author(s): Ricardo David Couto and Bruno Jose Dumêt Fernandes*

Volume 13, Issue 2, 2021

Published on: 26 January, 2021

Page: [86 - 89] Pages: 4

DOI: 10.2174/2589977513666210127094222

Price: $65


Naltrexone (NTX) is an opioid antagonist that inhibits cell proliferation in vivo when administered in low doses. Naltrexone in low doses can reduce tumor growth by interfering with cell signalling as well as by modifying the immune system. It acts as an Opioid Growth Factor receptor (OGFr) antagonist and the OGF-OGFr axis is an inhibitory biological pathway present in human cancer cells and tissues, being a target for the treatment with naltrexone low-dose (LDN). Clinical trials have proposed a unique mechanism(s) allowing LDN to affect tumors. LDN shows promising results for people with primary cancer of the bladder, breast, liver, lung, lymph nodes, colon and rectum. This short review provides further evidence to support the role of LDN as an anticancer agent.

Keywords: Low dose naltrexone, naltrexone, opioid growth factor receptor, cancer, tumor, and treatment.

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Graphical Abstract
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