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Current Catalysis


ISSN (Print): 2211-5447
ISSN (Online): 2211-5455

Research Article

Synthesis of New Chiral N-alkyl Betti-base Ligands via One-Pot Three Component Strategy

Author(s): Siva Ganesh, Kondabatini Sarika, Pedavenkatagari Narayana Reddy* and Pannala Padmaja*

Volume 10, Issue 1, 2021

Published on: 27 January, 2021

Page: [75 - 80] Pages: 6

DOI: 10.2174/2211544710666210127092335

Price: $65


Background: Betti base derivatives were employed as chiral ligands or as chiral auxiliaries in asymmetric transformations. In particular, N-alkyl Betti base derivatives are gaining importance as excellent ligands in asymmetric reactions. However, no appropriate method exists for regioselective N-alkylation of Betti base. Therefore, there is an urgent need to develop a new protocol for the regioselective N-alkylation of chiral Betti-base.

Methods: An efficient method has been developed for one-pot synthesis of chiral N-alkyl Bettibase ligands from (S)-(+)-Betti base, arylglyoxals and cyclic 1,3-C,N-binucleophiles under catalyst- free conditions.

Results: The chiral N-alkyl Betti-base ligands were obtained in good yields with excellent enantioselectivities. This method is rapid, clean and does not require a catalyst or chromatographic purification.

Conclusion: We have developed an efficient one-pot three component strategy for the synthesis of new chiral N-alkyl Betti-base ligands from (S)-(+)-Betti base, arylglyoxals and cyclic 1,3-C,Nbinucleophiles in the absence of a catalyst.

Keywords: Betti base, N-alkyl betti-base, arylglyoxals, 1, 3-C, N-binucleophiles, multicomponent reaction, asymmetric catalysis.

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