Propolis is a natural product made from the mixture of plant resin, saliva and wax collected by bees. It has been studied and concerned because of its high medicinal value and broad application prospects. Propolis has complex components, which can act on the body through multi-pathways and multi-targets to play the role of antibacterial, anti-inflammatory, anti-tumor and so on, and it can be used as an important resource for the prevention and treatment of oral diseases. In this review, we mainly reviewed components of propolis and its physiological activities against oral diseases, as well as the new dosage forms and applications of propolis in oral treatment. The purpose of this review is to explore the advantages of propolis in the treatment of oral diseases and the wide application of propolis in the field of oral health.