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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Research Article

Piroxicam Analogs: Design, Synthesis, Docking Study and Biological Evaluation as Promising Anti-HIV-1 Agents

Author(s): Ali Imani, Sepehr Soleymani, Rouhollah Vahabpour, Zahra Hajimahdi* and Afshin Zarghi*

Volume 18 , Issue 2 , 2022

Published on: 25 January, 2021

Page: [209 - 219] Pages: 11

DOI: 10.2174/1573406417666210125141639

Price: $65


Objective: In this study, we describe the synthesis, docking study and biological evaluation of 1,2-benzothiazines 1,1-dioxide derivatives.

Methods: Taking the well-known drug, Piroxicam as a lead compound, we designed and synthesized two series of 1,2-benzothiazines 1,1-dioxide derivatives to assay their ability in inhibition of HIV-1 replication in cell culture.

Results: Most of the new compounds were active in the cell-based anti-HIV-1 assay with EC50 < 50 μM. Among them, compound 7g was found to be the most active molecule.Docking study using 3OYA pdb code on the most active molecule 7g with EC50 values of 10 μM showed a similar binding mode to the HIV integrase inhibitors.

Conclusion: Since all the compounds showed no remarkable cytotoxicity (CC50> 500 μM), the designed scaffold is promising structure for the development of new anti-HIV-1 agents.

Keywords: Synthesis, docking, autodock vina, 1, 2-benzothiazines 1, 1-dioxide, piroxicam, anti-HIV-1, integrase.

Graphical Abstract
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