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Mini-Reviews in Organic Chemistry


ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Mini-Review Article

Insight View on Synthetic Strategies and Biological Applications of Pyrimidobenzothiazoles

Author(s): Dinesh Kumar Agarwal, Nusrat Sahiba, Ayushi Sethiya, Jay Soni, Pankaj Teli, Shikha Agarwal* and Pradeep Kumar Goyal

Volume 18, Issue 8, 2021

Published on: 22 January, 2021

Page: [1012 - 1025] Pages: 14

DOI: 10.2174/1570193X18666210122155016

Price: $65


Pyrimidobenzothiazoles and its derivatives are important structural scaffolds in the field of synthetic organic chemistry and medicinal chemistry. The review is focused on one pot multicomponent approaches for generating pyrimidobenzothiazoles and its derivatives along with their interesting biological profile over the last ten years. Several eco-benign and cost effective approaches such as nano catalyst, ionic liquid, metal, solid acid, catalyst free, solvent free, etc. for its synthesis have been discussed in this review. Different synthetic strategies of pyrimidobenzothiazole derivatives have been compiled and discussed using 2-aminobenzothiazole, 1,3 diketones, substituted aldehydes, alkynoic acid, bis-methyl thiomethylene malononitrile, Baylis Hillman acetates, etc.

Keywords: 2-aminobenzothiazole, multicomponent reaction, pyrimidobenzothiazole, synthetic approaches, biological profile, substituted aldehydes.

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