摘要
背景:由于银屑病是一种慢性、高患病率、致残、引发合并症和毁容的皮肤病,其具有挑战性。它是一种包括关节和代谢综合征的多系统疾病。银屑病是免疫细胞、生物信号分子和皮肤细胞之间病理相互作用的一种状态。遗传因素和环境因素,如药物、传染病和生活方式是促成银屑病恶化和发作的原因。 目的:研究银屑病治疗的新见解和未来前景。 方法:这篇综述文章深入了解了银屑病的当前概念,并讨论了疾病的发生和发展。我们描述了银屑病的发病途径。本文重点介绍了从炎症性银屑病通路的解剖中产生的银屑病的治疗方法。 结果:我们旨在突出用于治疗银屑病的新疗法和药物,包括食品和药物管理局 (FDA) 批准的药物和临床试验中的药物。可以使用维生素 D3 类似物、皮质类固醇和产品组合作为一线治疗针对轻度至中度疾病展开治疗。 结论:银屑病可以通过正确理解免疫功能来控制。我们还根据他们的民族药理学知识和研究人员报告的工作讨论了用于治疗牛皮癣的药材。
关键词: 银屑病斑块、炎症级联反应、T 细胞、草药、免疫。
Current Drug Targets
Title:Recent Advances in Psoriasis Therapy: Trends and Future Prospects
Volume: 22 Issue: 15
关键词: 银屑病斑块、炎症级联反应、T 细胞、草药、免疫。
摘要:
Background: Psoriasis is a challenging skin disorder due to its chronicity, high rate of prevalence, disability, comorbidity and disfiguration. It is a multi-system disorder that includes joints and metabolic syndromes. Psoriasis is a condition of pathologic interaction among immune cells, biological signaling molecules and skin cells. Several contributing factors are responsible for the exacerbation and onset of psoriasis, i.e. genetic factors and environmental factors such as medications, infectious diseases and lifestyle.
Objectives: To study the new insights in the treatment of psoriasis and future prospects.
Methods: This review article gives an insight on the current concepts of psoriasis and deals with discussing the initiation and development of the diseases. We described the pathogenetic pathway for psoriasis. The article focuses on the treatment approaches for psoriasis that have arisen from the dissection of the inflammatory psoriatic pathways.
Results: We aimed to highlight the novel therapies and drugs used in the treatment of psoriasis, including food and drug administration (FDA) approved drugs and drugs under clinical trials. The treatment can be initiated for mild to the moderate diseased condition employing vitamin D3 analogues, corticosteroids and a combination of products as first-line therapy.
Conclusion: Psoriasis can be managed by a proper understanding of the immune function. We have also discussed medicinal herbs used for psoriasis based on their ethnopharmacological knowledge and reported work of researchers.
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Cite this article as:
Recent Advances in Psoriasis Therapy: Trends and Future Prospects, Current Drug Targets 2021; 22 (15) . https://dx.doi.org/10.2174/1389450122666210118103455
DOI https://dx.doi.org/10.2174/1389450122666210118103455 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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